Shape and Size Effects of Gold Nanoparticles for Tumor Photoacoustic Imaging and Photothermal Therapy Within the NIR-I and NIR-II Biowindows
文献类型：期刊论文
| 作者 | Zeng, Xiaodong2,3,4; Tang, Lin2; Zhang, Weijing1,3,4; Hong, Xuechuan2,3,4; Xiao, Yuling2,3,4 |
| 刊名 | SMALL
 |
| 出版日期 | 2025-05-01 |
| 卷号 | 21期号:21页码:11 |
| 关键词 | cancer theranostics gold nanoparticles near-infrared window photoacoustic imaging photothermal therapy |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.202412296 |
| 英文摘要 | Gold nanoparticles (AuNPs) have emerged as promising tools in cancer theranostics, particularly in applications involving photoacoustic imaging (PAI) and photothermal therapy (PTT). The optical and thermal properties of AuNPs can be precisely tuned by adjusting their shape and size, which, in turn, influences their performance within the first (NIR-I) and second near-infrared (NIR-II) bio-windows. This study explores how variations in the morphology of AuNPs, such as nanorods and nanodumbbells, affect their longitudinal surface plasmon resonance peaks, penetration depth, heating efficiency, and photoacoustic performance. Special attention is given to the superior capabilities of PEGylated NIR-II AuNPs in deep tissue imaging, photothermal conversion efficiency, effective tumor ablation, and biocompatibility compared to their NIR-I counterparts. NIR-II AuNPs also demonstrate significantly enhanced photoacoustic intensity, making them highly promising for clinical PAI. These findings underscore the potential of NIR-II-optimized AuNPs as potent agents for cancer theranostics, providing valuable insights into how the shape and size of AuNPs influence the aspect ratio, thereby optimizing imaging precision and treatment efficacy across the NIR-I to NIR-II spectrum. |
| WOS关键词 | NANORODS |
| 资助项目 | National Key R&D Program of China ; National Natural Science Foundation of China[21204069] ; National Natural Science Foundation of China[22477129] ; Shandong Laboratory Program[SYS202205] ; Natural Science Foundation of Shandong Province[ZR2023MB085] ; Natural Science Foundation of Shandong Province[ZR2024QH253] ; Taishan Scholar Project[tsqn202306320] ; [2020YFA0908800] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001495042200007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317965]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zeng, Xiaodong; Xiao, Yuling |
| 作者单位 | 1.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China 2.Wuhan Univ, Zhongnan Hosp, Clin Trial Ctr, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Xiaodong,Tang, Lin,Zhang, Weijing,et al. Shape and Size Effects of Gold Nanoparticles for Tumor Photoacoustic Imaging and Photothermal Therapy Within the NIR-I and NIR-II Biowindows[J]. SMALL,2025,21(21):11. |
| APA | Zeng, Xiaodong,Tang, Lin,Zhang, Weijing,Hong, Xuechuan,&Xiao, Yuling.(2025).Shape and Size Effects of Gold Nanoparticles for Tumor Photoacoustic Imaging and Photothermal Therapy Within the NIR-I and NIR-II Biowindows.SMALL,21(21),11. |
| MLA | Zeng, Xiaodong,et al."Shape and Size Effects of Gold Nanoparticles for Tumor Photoacoustic Imaging and Photothermal Therapy Within the NIR-I and NIR-II Biowindows".SMALL 21.21(2025):11. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。