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Synergistic enhancement of desferrioxamine and strontium-doped hydroxyapatite via coaxial electrostatic spinning on osteogenic differentiation

文献类型：期刊论文

作者Liu, Yongman5; Wang, Yubin5; Meng, Wenxin4; Zhang, Wenjing5; Feng, Shuo3; Wu, Shangquan1,2
刊名BIOMATERIALS ADVANCES
出版日期2025-11-01
卷号176页码:13
关键词Strontium Hydroxyapatite Desferrioxamine Electrospun nanofiber membrane Osteogenic differentiation
DOI10.1016/j.bioadv.2025.214342
通讯作者Liu, Yongman(liuym@ahmu.edu.cn) ; Feng, Shuo(sfeng18@ustc.edu.cn) ; Wu, Shangquan(wushq@ustc.edu.cn)
英文摘要Defective bone repair is a pressing issue in the field of bone regeneration due to donor shortages and the associated complications of bone grafting. Artificial bone repair materials offer more options and are attracting extensive attention from researchers. However, achieving efficient osteogenesis in clinical practice remains a challenge. Here, dual drug-releasing nanofibre membranes (NMs) for bone repair was fabricated by coaxial electrostatic spinning. Strontium-doped hydroxyapatite (SrHA) and desferrioxamine (DFO) were loaded into the shell and core of the NMs for slow and sustained release, respectively. Our results showed that the DFO/SrHA NMs significantly enhanced cell proliferation, angiogenesis and osteogenic differentiation of rat bone mesenchymal stem cells through the synergism of DFO and SrHA. This synergy results from the slow and sustained release of DFO and SrHA via NMs, which maintains the drug concentration in the effective range for a long time, ensuring long-term stable activation of the HIF-1 alpha and Wnt/beta-catenin signalling pathways. Overall, the DFO/SrHA NMs provides a promising strategy for defective bone repair by enhancing osteogenic differentiation.
分类号二类
WOS关键词BONE DEFECT ; ANGIOGENESIS ; SCAFFOLD ; DELIVERY ; MATRIX ; REPAIR
资助项目National Natural Science Foundation of China[12222212] ; National Natural Science Foundation of China[22303088] ; National Natural Science Foundation of China[22393892] ; Fundamental Research Funds for the Central Universities, China[WK9990000129]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:001500787100001
资助机构National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities, China
其他责任者Liu, Yongman，Feng, Shuo，Wu, Shangquan
源URL[http://dspace.imech.ac.cn/handle/311007/101760]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
2.Univ Sci & Technol China, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei 230026, Peoples R China;
3.Univ Sci & Technol China, State Key Lab Precis & Intelligent Chem, Hefei 230026, Peoples R China;
4.Anhui Med Univ, Coll & Hosp Stomatol, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Peoples R China;
5.Anhui Med Univ, Sch Biomed Engn, Hefei 230032, Peoples R China;
推荐引用方式
GB/T 7714		 Liu, Yongman,Wang, Yubin,Meng, Wenxin,et al. Synergistic enhancement of desferrioxamine and strontium-doped hydroxyapatite via coaxial electrostatic spinning on osteogenic differentiation[J]. BIOMATERIALS ADVANCES,2025,176:13.
APA Liu, Yongman,Wang, Yubin,Meng, Wenxin,Zhang, Wenjing,Feng, Shuo,&Wu, Shangquan.(2025).Synergistic enhancement of desferrioxamine and strontium-doped hydroxyapatite via coaxial electrostatic spinning on osteogenic differentiation.BIOMATERIALS ADVANCES,176,13.
MLA Liu, Yongman,et al."Synergistic enhancement of desferrioxamine and strontium-doped hydroxyapatite via coaxial electrostatic spinning on osteogenic differentiation".BIOMATERIALS ADVANCES 176(2025):13.

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来源：力学研究所

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