Daphnane Diterpenoids from Daphne retusa with Antiadipogenic Activity: Concurrent Suppression of Lipid Biosynthesis and Enhancement of Metabolic Pathways
文献类型：期刊论文
| 作者 | Song, Xiu-Qing3,4; Guo, Yue2,3; Wang, Xin2,3 ; Song, Qin-Qin1,4; Fan, Yao-Yue2,3,4
|
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2025-06-05 |
| 卷号 | 88期号:6页码:1514-1525 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.5c00390 |
| 通讯作者 | Fan, Yao-Yue(s040500290@126.com) |
| 英文摘要 | Phytochemical investigation of the rarely studied Daphne retusa employing molecular networking and bioactivity-guided strategies led to the identification of 12 daphnane diterpenoids (1-12), including seven previously undescribed compounds, daphretusins A-G (1-7). Structural elucidation was achieved through comprehensive spectroscopic analysis (HRESIMS, 1D/2D NMR), combined with experimental and calculated electronic circular dichroism (ECD), NMR calculations, and DP4+ analysis. All isolates demonstrated potent dose-dependent antiadipogenic effects, inhibiting lipid accumulation in 3T3-L1 cells with EC50 values ranging from 0.07 to 4.2 mu M. Mechanistic studies revealed a dual mode of action, with compound 11 serving as a representative example for its potent bioactivity and exceptional selectivity: it concurrently (1) inhibited lipid biosynthesis via downregulation of key adipogenic transcription factors (PPAR gamma, C/EBP alpha, and SREBP-1) and lipogenic enzymes (FASN, ACC, and SCD1), while (2) promoting lipid metabolism through CPT-1-mediated activation of beta-oxidation. |
| WOS关键词 | ESTERS |
| 资助项目 | Key Technology Research and Development Program of Shandong Province[2024CXPt029] ; Key R&D Program of Shandong Province, China[tsqn202408315] ; Taishan Scholars Program[XDB1060000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[82122062] ; National Natural Science Foundation of China[SYS24A04] ; Yantai New Drug Creation Shandong Provincial Laboratory Innovation Research Project |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001502873900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318186]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fan, Yao-Yue |
| 作者单位 | 1.Shihezi Univ, Coll Life Sci, Shihezi 832003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 4.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Xiu-Qing,Guo, Yue,Wang, Xin,et al. Daphnane Diterpenoids from Daphne retusa with Antiadipogenic Activity: Concurrent Suppression of Lipid Biosynthesis and Enhancement of Metabolic Pathways[J]. JOURNAL OF NATURAL PRODUCTS,2025,88(6):1514-1525. |
| APA | Song, Xiu-Qing,Guo, Yue,Wang, Xin,Song, Qin-Qin,&Fan, Yao-Yue.(2025).Daphnane Diterpenoids from Daphne retusa with Antiadipogenic Activity: Concurrent Suppression of Lipid Biosynthesis and Enhancement of Metabolic Pathways.JOURNAL OF NATURAL PRODUCTS,88(6),1514-1525. |
| MLA | Song, Xiu-Qing,et al."Daphnane Diterpenoids from Daphne retusa with Antiadipogenic Activity: Concurrent Suppression of Lipid Biosynthesis and Enhancement of Metabolic Pathways".JOURNAL OF NATURAL PRODUCTS 88.6(2025):1514-1525. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。