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Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping

文献类型：期刊论文

作者Cao, Zeying4,5,6; Zhou, Shilin4; Zhao, Yanli4; Wu, Qian3,6; Huang, Chenxi2,4; Nie, Qin3,6; Xiong, Ting3,6; Hao, Xiaoxu4; Zhang, Shuo4; Bao, Haojie3,6
刊名ACS NANO
出版日期2025-06-04
卷号19期号:25页码:23414-23430
关键词three-dimensional pathology nanogrid ROS-scavenging tracheal targeted bronchitis nano-bio-interactions
ISSN号1936-0851
DOI10.1021/acsnano.5c06694
通讯作者Zhang, Jiwen(jwzhang@simm.ac.cn) ; Yin, Xianzhen(xzyin@lglab.ac.cn)
英文摘要Current clinical treatment of pulmonary diseases requires an advanced three-dimensional (3D) pathological atlas of the microenvironment, particularly the trachea, which is predominantly affected by lung disorders. In this study, the gridded cyclodextrin cross-links (GCC) exhibited enzymatic activities and served as a metal-free nanozyme. A specific biodistribution of GCC nanogrid around the trachea had been observed using a fluorescence micro-optical sectioning tomography system. The effective loading of dexamethasone (DEX) allowed for the construction of DEX@GCC nanogrid system, which exhibited a sustained-release profile and a preferable lung targeting in vivo. Additionally, DEX@GCC demonstrated improved efficacy in treating lipopolysaccharide-induced bronchitis of mice at lower dosages compared with the positive control. A 3D pathological assessment based on the micro-optical sectioning tomography system and high-content data analysis with machine learning validated the superiority of the GCC nanogrid for identifying inflammatory cells, quantifying tracheal wall thickness, and virtual endoscopy. In conclusion, the tracheal localization and ROS-responsive behaviors of the GCC nanogrid provide a cross-scale visualization strategy for evaluating nanoparticle biodistribution and advancing pulmonary disease treatment.
WOS关键词CHRONIC-BRONCHITIS ; CHOLESTEROL DEPLETION ; LUNG ; COPD ; PHENOTYPE ; COUGH ; SIZE
资助项目National Natural Science Foundation of China[82273863] ; National Natural Science Foundation of China[23XD1460400] ; Shanghai excellent academic leader ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences ; Shanghai Advanced Research Institute, Chinese Academy of Sciences, China
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001502850800001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/318192]  
专题中国科学院上海药物研究所
通讯作者Zhang, Jiwen; Yin, Xianzhen
作者单位1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China
2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Pharm, Benxi 117000, Peoples R China
4.Lingang Lab, Shanghai 201602, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Zeying,Zhou, Shilin,Zhao, Yanli,et al. Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping[J]. ACS NANO,2025,19(25):23414-23430.
APA Cao, Zeying.,Zhou, Shilin.,Zhao, Yanli.,Wu, Qian.,Huang, Chenxi.,...&Yin, Xianzhen.(2025).Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping.ACS NANO,19(25),23414-23430.
MLA Cao, Zeying,et al."Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping".ACS NANO 19.25(2025):23414-23430.

入库方式： OAI收割

来源：上海药物研究所

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