Mechanism of HJ11 Decoction in the Treatment of Atherosclerosis Based on Network Pharmacology and Experimental Validation
文献类型：期刊论文
| 作者 | Lu, Fei9,10; Zou, Jiaxi8; Xu, Weiming5,6,7; Zhang, Fangyuan3,4; Nie, Wenyi2; Zhao, Yue2; Jiang, Lijie6; Liang, Lizhe9; Hu, Jingqing1,6,10 |
| 刊名 | COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
 |
| 出版日期 | 2025-01-21 |
| 页码 | 16 |
| 关键词 | HJ11 decoction atherosclerosis network pharmacology molecular docking inflammation oral bioavailability |
| ISSN号 | 1386-2073 |
| DOI | 10.2174/0113862073356770241218065012 |
| 通讯作者 | Hu, Jingqing(hujq@jiicm.org.cn) |
| 英文摘要 | Background HJ11 (HJ11 decoction), which is based on the traditional prescription Si-Miao-Yong-An decoction, has exerted a remarkable effect on atherosclerosis (AS). Nevertheless, the main components and underlying mechanisms of HJ11 for treating AS remain unclear.Aim of the Study This study was designed to elucidate the mechanism of HJ11 in the treatment of AS through network pharmacology and in vivo experimental validation.Methods Network pharmacology was employed to explore the primary bioactive components and targets of HJ11. AS-related genes were obtained from the GeneCards and DisGeNET databases and screened for intersections with HJ11. A herb-compound-target interaction network was constructed by Cytoscape 3.9.1, and molecular docking analyses were constructed on key targets. By using a mouse model, the mechanism of action of HJ11 was further confirmed.Results A total of 231 active components of HJ11, 1681 AS-related genes, and 156 common targets were identified. Through the establishment of numerous networks, it was discovered that the main association of the mechanism of HJ11 in AS therapy pertained to anti-inflammation. Important substances included quercetin, kaempferol, and luteolin, while TNF-alpha, AKT1, IL-6, and VEGFA were the main targets. Molecular docking demonstrated that there were favorable binding interactions between active drugs (quercetin, kaempferol, and luteolin) and targets (TNF-alpha, AKT1, IL-6, and VEGFA). In the in vivo study, HJ11 reduced the expression of TNF-alpha, AKT1, IL-6, and VEGFA at both the mRNA and protein levels, inhibited atherosclerotic lesions in AS mouse models, and retarded the development of retroarterioid sclerosis.Conclusions HJ11 can inhibit inflammation and the progression of AS, and the mechanism might involve downregulating the expression of TNF-alpha, AKT1, IL-6, and VEGFA. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; ATTENUATES ATHEROSCLEROSIS ; INFLAMMATION ; QUERCETIN ; PATHOGENESIS ; SECRETION ; STRESS ; CELLS |
| 资助项目 | National Key Research and Development Program of China[2019YFC1708501] ; Foshan Science and Technology Innovation Project[2020001005585] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001498578400001 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318204]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, Jingqing |
| 作者单位 | 1.Tianjin Univ Chinese Med, Tianjin, Peoples R China 2.Changchun Univ Tradit Chinese Med, Changchun, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou, Peoples R China 5.Henan Univ Chinese Med, Affiliated Hosp 1, Zhengzhou, Peoples R China 6.China Acad Chinese Med Sci, Inst Basic Theory Chinese Med, Beijing, Peoples R China 7.China Sci & Technol Dev Ctr Chinese Med, Beijing, Peoples R China 8.Hosp Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China 9.Liaoning Univ Tradit Chinese Med, Affiliated Hosp 2, Shenyang, Peoples R China 10.Liaoning Univ Tradit Chinese Med, Clin Dept, Shenyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Fei,Zou, Jiaxi,Xu, Weiming,et al. Mechanism of HJ11 Decoction in the Treatment of Atherosclerosis Based on Network Pharmacology and Experimental Validation[J]. COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,2025:16. |
| APA | Lu, Fei.,Zou, Jiaxi.,Xu, Weiming.,Zhang, Fangyuan.,Nie, Wenyi.,...&Hu, Jingqing.(2025).Mechanism of HJ11 Decoction in the Treatment of Atherosclerosis Based on Network Pharmacology and Experimental Validation.COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING,16. |
| MLA | Lu, Fei,et al."Mechanism of HJ11 Decoction in the Treatment of Atherosclerosis Based on Network Pharmacology and Experimental Validation".COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2025):16. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。