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Gastrodia elata Blume extract alleviates sepsis-induced lung injury by suppressing IL-23/IL-17 A axis

文献类型：期刊论文

作者Dong, Huiqing6,7; Zhang, Yun7; Zhou, Yang4; Zhang, Menghui3,6; Zhang, Lei6; Feng, Jing5,6,7; Wu, Wanying4; Liu, Yifei6; Wang, Ting1,2,5,6
刊名FITOTERAPIA
出版日期2025-07-01
卷号184页码:12
关键词Gastrodia elata Blume extract Sepsis-induced lung injury IL-23/IL-17 A axis Neutrophil infiltration
ISSN号0367-326X
DOI10.1016/j.fitote.2025.106624
通讯作者Wang, Ting(wangting@simm.ac.cn)
英文摘要The Compendium of Materia Medica recorded that the traditional Chinese medicine Gastrodia elata Blume (G. elata) has applications in antibacterial and antiviral. GE05 was prepared from the rhizome of G. elata and its active ingredients have been proven to alleviate inflammatory response. However, the protective effect and the underlying mechanism of G. elata in sepsis remain unclear. Our study aims to uncover the efficacy and molecular mechanisms of GE05 in ameliorating sepsis-induced lung injury. Here, we have shown that GE05 could inhibit the expression of inflammatory cytokines in peritoneal macrophages. Bioinformatics analysis showed the activation of interleukin (IL)-17 signaling pathway in acute lung injury (ALI) mice. We established septicemia models and showed that GE05 improves survival rates and protects against sepsis-induced lung injury by downregulating the IL-23/IL-17 A axis. Quantitative real- time PCR (qPCR) analysis and immunohistochemistry have indicated that IL-17 A inhibition reduces the release of chemokine ligand (Cxcl) 1, Cxcl2, granulocytemacrophage colony stimulating factor (GM-CSF), and granulocyte colony-stimulating factor (G-CSF), mitigating neutrophil infiltration-induced lung tissue damage. Meanwhile, GE05 could inhibit the activation of the IL-17 Arelated phosphatidylinositol 3-kinase/ c-Jun N-terminal kinase (PI3K/JNK) signaling pathway, suppressing the expression of tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, and IL-6. These results demonstrated that GE05 is a promising agent that targets the IL-23/IL-17 A axis, providing new way for preventing and treating sepsisinduced lung injury.
WOS关键词INFLAMMATION ; MODULATION
资助项目National Key Research and Development Program of China[2024YFC3505305] ; Shanghai Municipal Natural Science Foundation[23ZR1474500] ; National Science Foundation of China[82171214] ; National Science Foundation of China[32241003] ; National Science Foundation of China[82471233] ; National Science Foundation of China[U24A20783] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB1060000] ; Research Project of Yunnan Key Laboratory of Gastrodia[TMKF2024B01]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001498628100001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/318225]  
专题中国科学院上海药物研究所
通讯作者Wang, Ting
作者单位1.Zhaotong Univ, Yunnan Key Lab Gastrodia & Fungi Symbiot Biol, Zhaotong 657000, Yunnan, Peoples R China
2.Zhaotong Univ, Yunnan Engn Res Ctr Green Planting & Proc Gastrodi, Zhaotong 657000, Yunnan, Peoples R China
3.Henan Univ, Sch Pharm, Kaifeng 475001, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr TCM Modernizat, Natl Engn Lab TCM Standardizat Technol, Shanghai 201203, Peoples R China
5.Univ Chinese Acad Sci, Beijing 101408, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
7.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Dong, Huiqing,Zhang, Yun,Zhou, Yang,et al. Gastrodia elata Blume extract alleviates sepsis-induced lung injury by suppressing IL-23/IL-17 A axis[J]. FITOTERAPIA,2025,184:12.
APA Dong, Huiqing.,Zhang, Yun.,Zhou, Yang.,Zhang, Menghui.,Zhang, Lei.,...&Wang, Ting.(2025).Gastrodia elata Blume extract alleviates sepsis-induced lung injury by suppressing IL-23/IL-17 A axis.FITOTERAPIA,184,12.
MLA Dong, Huiqing,et al."Gastrodia elata Blume extract alleviates sepsis-induced lung injury by suppressing IL-23/IL-17 A axis".FITOTERAPIA 184(2025):12.

入库方式： OAI收割

来源：上海药物研究所

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