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Chemical constituents with immunosuppressive and antitumor activities of Tetradium fraxinifolium (Hook.) TGHartley

文献类型：期刊论文

作者Du, En-Lian4,5; Tan, Jun-Jie4; Wang, Yi3; Jiang, Yu-Xia4,5; Chen, Fei2,4; Li, Sai4,5; Meng, Lin-Hua2,3; He, Shi-Jun1; Tan, Chang-Heng2,4,5
刊名FITOTERAPIA
出版日期2025-07-01
卷号184页码:6
关键词Rutaceae Tetradium fraxinifolium Limonoids Alkaloids Immunosuppressant Antitumor
ISSN号0367-326X
DOI10.1016/j.fitote.2025.106636
通讯作者Meng, Lin-Hua(lhmeng@simm.ac.cn) ; He, Shi-Jun(heshijun@shutcm.edu.cn) ; Tan, Chang-Heng(chtan@simm.ac.cn)
英文摘要Five new constituents, fraxinifolines H (1) and J (2), 7S-O-beta-D-glucopyranosylrutaecarpine (6), 12-hydroxyhortiamide (10) and fraxinifolioside A (13), together with known limonoids (3-5) and alkaloids (7-9 and 11-12) were isolated from the twigs with leaves of Tetradium fraxinifolium. The structures of these compounds were determined by analysis of their HRESIMS, NMR spectroscopic data, and/or single crystal X-ray diffraction. Compounds 1, 2, 4, and 7-13 exhibited immunesuppressive activity in vitro against the proliferation of LPSinduced B lymphocytes and/or ConA-induced T cells. While 3 showed significant anti-proliferation effect on HT-29 human colon cancer cells.
资助项目National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of the National Health Commission of China[2019ZX09201001]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001501714300001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/318237]  
专题中国科学院上海药物研究所
通讯作者Meng, Lin-Hua; He, Shi-Jun; Tan, Chang-Heng
作者单位1.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Res Ctr, Shanghai 201203, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Du, En-Lian,Tan, Jun-Jie,Wang, Yi,et al. Chemical constituents with immunosuppressive and antitumor activities of Tetradium fraxinifolium (Hook.) TGHartley[J]. FITOTERAPIA,2025,184:6.
APA Du, En-Lian.,Tan, Jun-Jie.,Wang, Yi.,Jiang, Yu-Xia.,Chen, Fei.,...&Tan, Chang-Heng.(2025).Chemical constituents with immunosuppressive and antitumor activities of Tetradium fraxinifolium (Hook.) TGHartley.FITOTERAPIA,184,6.
MLA Du, En-Lian,et al."Chemical constituents with immunosuppressive and antitumor activities of Tetradium fraxinifolium (Hook.) TGHartley".FITOTERAPIA 184(2025):6.

入库方式： OAI收割

来源：上海药物研究所

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