Cyclodextrin metal-organic framework design principles and functionalization for biomedical application
文献类型：期刊论文
| 作者 | Bello, Mubarak G.2,3; Zhang, Jiwen1 ; Chen, Lihua3
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2025-09-15 |
| 卷号 | 364页码:21 |
| 关键词 | Cyclodextrin Metal-organic framework Crystal engineering Post-synthesis modification Biomedical application |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2025.123684 |
| 通讯作者 | Zhang, Jiwen(jwzhang@simm.ac.cn) ; Chen, Lihua(chlly98@163.com) |
| 英文摘要 | Cyclodextrin based metal-organic frameworks (CD-MOFs) have emerged as a groundbreaking class of biomaterials, combining biocompatibility, structural versatility, and tunable porosity for diverse applications. Despite their promise, challenges such as aqueous instability, scalability, and precise functionalization hinder their full potential. This review systematically examines CD-MOF design principles, synthesis strategies, and post-synthetic modifications to address these limitations. We highlight the relationship between framework architecture and drug encapsulation/release mechanisms, offering insights into enhancing therapeutic efficacy. Advanced functionalization techniques including ligand grafting, stimuli-responsive systems, and hybrid composites are explored to improve stability and targeting precision. Furthermore, we discuss CD-MOF composites for scalable drug delivery and sensing applications. Safety profiles and industrial challenges are thoroughly explored, with forward-looking perspectives on AI-driven solutions. This review establishes a foundational framework for CD-MOFs, highlighting their transformative potential in biomedical application. The insights gained here will guide the development of next-generation CD-MOFs, leveraging their unique properties to advance biomedical research and clinical applications. |
| WOS关键词 | CD-MOF ; FACILE STABILIZATION ; ALPHA-CYCLODEXTRIN ; CRYSTAL-GROWTH ; DRUG ; SOLUBILITY ; NANOPARTICLES ; INCLUSION ; STABILITY ; STRATEGY |
| 资助项目 | National Natural Science Foundation of China[82160752] ; Key Technological Project of Jiangxi Province[20212AAF01005] ; Key Technological Project of Jiangxi Province[20223AAF01007] ; Jiangxi University of Traditional Chinese Medicine Science and Technology Innovation Team Development Program[CXTD-22004] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001501336900003 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318240]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jiwen; Chen, Lihua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 2.Kaduna State Univ, Dept Pharmaceut & Ind Pharm, Kaduna 800244, Nigeria 3.Jiangxi Univ Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, 1688 Meiling Rd, Nanchang 330004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bello, Mubarak G.,Zhang, Jiwen,Chen, Lihua. Cyclodextrin metal-organic framework design principles and functionalization for biomedical application[J]. CARBOHYDRATE POLYMERS,2025,364:21. |
| APA | Bello, Mubarak G.,Zhang, Jiwen,&Chen, Lihua.(2025).Cyclodextrin metal-organic framework design principles and functionalization for biomedical application.CARBOHYDRATE POLYMERS,364,21. |
| MLA | Bello, Mubarak G.,et al."Cyclodextrin metal-organic framework design principles and functionalization for biomedical application".CARBOHYDRATE POLYMERS 364(2025):21. |
入库方式： OAI收割
来源：上海药物研究所
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