Biotransformation of artemisinin by human intestinal fungi and cytotoxicity against breast cancer cells of its metabolites
文献类型：期刊论文
| 作者 | He, Xin4,5; Wei, Xuemei3; He, Zhong2; Yao, Changliang4; Nie, Min4; Ma, Xiaochi1; Chen, Qinhua3; Guo, De-an4,5
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2025-10-01 |
| 卷号 | 238页码:7 |
| 关键词 | Artemisinin Biotransformation Intestinal fungi Cytotoxicity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2025.114551 |
| 通讯作者 | Chen, Qinhua(cqh77@163.com) ; Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Artemisinin widely exists in the Artemisia annua L. and is the front-line of antimalarial drugs. In this study, microbial transformation of artemisinin was performed based on seventeen human intestinal fungal species. Our findings revealed that isomerization and deoxygenation were the most prevalent metabolic pathways in fungi. Incubation of artemisinin with Rhizopus microspores (PT2906) and Candida boidinii (M7017B) afforded three new compounds (P3, P5 and P6) along with seven known metabolites which were elucidated by extensive spectroscopic data analysis. All metabolites were evaluated for their cytotoxicity against MCF-7 cells, and the results showed that 3 beta-hydroxydeoxyartemisinin (P5) suppressed the growth of MCF-7 cells better than artemisinin. In addition, ten artemisinin isomers were found in the feces of antibiotic-treated mice after M7017B transplantation, demonstrating that human intestinal fungi have the potential to participate in the in vivo intestinal transformation of artemisinin. |
| WOS关键词 | MICROBIAL-METABOLISM |
| 资助项目 | Sanming Project of Medicine in Shenzhen[SZZYSM202106004] ; National Natural Science Foundation of China[82272960] ; Scientific Research Project of the Guangdong Provincial Administration of Traditional Chinese Medicine[20252037] ; Caojunling National Veteran Pharmaceutical Worker Inheritance Studio |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001502425700001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318252]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Qinhua; Guo, De-an |
| 作者单位 | 1.Dalian Med Univ, Affiliated Hosp 2, Pharmaceut Res Ctr, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Chem Biol, Shanghai 201203, Peoples R China 3.Shenzhen Baoan Authent TCM Therapy Hosp, Shenzhen 518101, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China 5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Xin,Wei, Xuemei,He, Zhong,et al. Biotransformation of artemisinin by human intestinal fungi and cytotoxicity against breast cancer cells of its metabolites[J]. PHYTOCHEMISTRY,2025,238:7. |
| APA | He, Xin.,Wei, Xuemei.,He, Zhong.,Yao, Changliang.,Nie, Min.,...&Guo, De-an.(2025).Biotransformation of artemisinin by human intestinal fungi and cytotoxicity against breast cancer cells of its metabolites.PHYTOCHEMISTRY,238,7. |
| MLA | He, Xin,et al."Biotransformation of artemisinin by human intestinal fungi and cytotoxicity against breast cancer cells of its metabolites".PHYTOCHEMISTRY 238(2025):7. |
入库方式： OAI收割
来源：上海药物研究所
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