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Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors

文献类型：期刊论文

作者Zhang, Ping5,6,7; Pan, Jiaxing1,5,6; Lin, Shutong5,6; Peng, Bo4; An, Caiyan3; Zhang, Junjing2; Xu, Leiming1; Lai, Yi5,6; Yu, Haijun5,6; Xu, Zhiai7
刊名ADVANCED DRUG DELIVERY REVIEWS
出版日期2025-09-01
卷号224页码:27
关键词Pancreatic cancer Cancer immune cycle Immune resistance Drug delivery systems Stimuli-responsive
ISSN号0169-409X
DOI10.1016/j.addr.2025.115620
通讯作者Zhang, Junjing(zhang.jj@vip.163.com) ; Lai, Yi(laiyi@simm.ac.cn) ; Yu, Haijun(hjyu@simm.ac.cn) ; Xu, Zhiai(zaxu@chem.ecnu.edu.cn)
英文摘要Immunotherapy has emerged as a promising strategy for pancreatic ductal adenocarcinoma (PDAC) therapy, yet its clinical efficacy suffers from the immunosuppressive tumor microenvironment (ITM). This ITM contributes to immune resistance by impeding the cancer immune (CI) cycle at multiple stages, including impaired antigen release and presentation, inadequate T cell priming and activation, restricted T cell infiltration, and compromised T cell cytotoxicity within the tumor. To address these challenges, smart drug delivery systems have emerged as a transformative strategy to precisely modulate the CI cycle, thereby reversing the ITM and restoring the anti-tumor immunity. In this review, we systematically dissect the clinical landscape of PDAC immunotherapy, outline key mechanisms of impaired CI cycle to drive immunotherapy resistance, and explore smart drug delivery platforms for reinitiating CI cycle. We further discuss the latest preclinical advances of precisely engineered drug delivery systems, and provide a perspective on their potential to harness the CI cycle and overcome immunotherapy resistance in PDAC. This review not only summarizes current progress but also provides a forward-looking perspective on next-generation immunotherapies, emphasizing the role of neuroimmune interactions and the rational design of spatiotemporally tunable, circadian rhythm-adaptable drug delivery systems.
WOS关键词T-CELL IMMUNOTHERAPY ; ACQUIRED-RESISTANCE ; METABOLISM ; STRATEGIES ; THERAPY ; SUPPORT ; PD-L1 ; ADENOCARCINOMA ; INFLAMMATION ; FIBROBLASTS
资助项目National Natural Science Foundation of China[82203041] ; National Natural Science Foundation of China[32311530041] ; National Natural Science Foundation of China[U22A20328] ; National Natural Science Foundation of China[W2412035] ; Science and Technology Commission of Shanghai Municipality[23ZR1475000] ; Science and Technology Commission of Shanghai Municipality[24430713500] ; Science and Technology Commission of Shanghai Municipality[23490712700]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001504827900001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/318285]  
专题中国科学院上海药物研究所
通讯作者Zhang, Junjing; Lai, Yi; Yu, Haijun; Xu, Zhiai
作者单位1.Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Gastroenterol, Shanghai 2000092, Peoples R China
2.Hohhot First Hosp, Dept Hepatobiliary Surg, Dept Surg, Hohhot 010030, Peoples R China
3.Hohhot First Hosp, Fdn & Translat Med Res Ctr, Inner Mongolia Key Lab Allerg Dis, Hohhot 010030, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Informat Ctr, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, State Key Lab Chem Biol, Shanghai 201203, Peoples R China
7.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Ping,Pan, Jiaxing,Lin, Shutong,et al. Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors[J]. ADVANCED DRUG DELIVERY REVIEWS,2025,224:27.
APA Zhang, Ping.,Pan, Jiaxing.,Lin, Shutong.,Peng, Bo.,An, Caiyan.,...&Xu, Zhiai.(2025).Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors.ADVANCED DRUG DELIVERY REVIEWS,224,27.
MLA Zhang, Ping,et al."Smart drug delivery platforms reprogramming cancer immune cycle to mitigate immune resistance of pancreatic tumors".ADVANCED DRUG DELIVERY REVIEWS 224(2025):27.

入库方式： OAI收割

来源：上海药物研究所

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