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Concise synthesis of NDP-activated uronic acid by an oxidation reaction insertion strategy

文献类型：期刊论文

作者Yang, Nana4; Yuan, Rui5; Fu, Xinyue3,4,5; Tian, Xiao2,4; Yu, Jin1; Ma, Shengzhou5; Wen, Liuqing3,5; Zhang, Jiabin3,4,5
刊名CHINESE CHEMICAL LETTERS
出版日期2025-08-01
卷号36期号:8页码:7
关键词NDP-uronic acids Biocatalysis Enzyme-mediated biomimetic synthesis Oxidation reaction insertion strategy
ISSN号1001-8417
DOI10.1016/j.cclet.2024.110757
通讯作者Wen, Liuqing(lwen@simm.ac.cn) ; Zhang, Jiabin(jiabinzhang@simm.ac.cn)
英文摘要Uronic acids are prevalent components of crucial glycoconjugates, pivotal in various biological processes. In nature, NDP-uronic acids, the nucleosides-activated uronic acids, serve as glycosylation donors catalyzed by uronosyltransferases (UATs) to construct glycans containing uronic acids. Despite their biological importance, the synthesis of naturally occurring NDP-uronic acids on a large scale remains challenging. Here, we developed an oxidation reaction insertion strategy for the efficient synthesis of NDP-uronic acids, and 11 NDP-uronic acids were successfully prepared in good yield and on a large scale. The prepared NDP-uronic acids can be used to explore new uronosyltransferases and synthesize uronic acids containing carbohydrates for fundamental research. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
WOS关键词CHEMOENZYMATIC SYNTHESIS ; CAPSULAR POLYSACCHARIDE ; HEPARAN-SULFATE ; BIOSYNTHESIS ; SUGARS ; NOMENCLATURE ; NUCLEOTIDES ; ENZYME
资助项目National Natural Science Foundation of China[22207113] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110588] ; Natural Science Foundation of Shanghai Municipal-ity[22ZR1474000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001505137700004
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/318300]  
专题中国科学院上海药物研究所
通讯作者Wen, Liuqing; Zhang, Jiabin
作者单位1.Imperial Coll London, Dept Metab Digest & Reprod, London W12 0NN, England
2.Zunyi Med Univ, Sch Pharm, Zunyi 563006, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Guangdong, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Prov Carbohydrate Based Drug Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Nana,Yuan, Rui,Fu, Xinyue,et al. Concise synthesis of NDP-activated uronic acid by an oxidation reaction insertion strategy[J]. CHINESE CHEMICAL LETTERS,2025,36(8):7.
APA Yang, Nana.,Yuan, Rui.,Fu, Xinyue.,Tian, Xiao.,Yu, Jin.,...&Zhang, Jiabin.(2025).Concise synthesis of NDP-activated uronic acid by an oxidation reaction insertion strategy.CHINESE CHEMICAL LETTERS,36(8),7.
MLA Yang, Nana,et al."Concise synthesis of NDP-activated uronic acid by an oxidation reaction insertion strategy".CHINESE CHEMICAL LETTERS 36.8(2025):7.

入库方式： OAI收割

来源：上海药物研究所

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