中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 上海药物研究所
  3. 中国科学院上海药物研究所
Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer

文献类型：期刊论文

作者Chen, Mingcang3,4; Zhou, Ying2; Fu, Zhengwei4; Wu, Chunyu1
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
出版日期2025-12-01
卷号57期号:5页码:818-833
关键词intercellular adhesion molecule 1 competition DNA methylation transcription factor binding breast cancer
ISSN号1672-9145
DOI10.3724/abbs.2024237
通讯作者Fu, Zhengwei(azwfu@zjut.edu.cn) ; Wu, Chunyu(chunyuwu@shutcm.edu.cn)
英文摘要The interaction between TF binding and DNA methylation is increasingly recognized as a key player in the regulation of gene expression. However, the role of this interaction in regulating ICAM1 expression in breast cancer has not been elucidated. CpG methylation in the ICAM1 promoter is negatively correlated with ICAM1 expression, and ICAM1 expression is significantly positively correlated with DNMT and TET3 expression in breast cancer. TF binding attenuates ICAM1 promoter CpG methylation and promotes ICAM1 transcription. DNA methylation regulation enhances ICAM1 expression in breast cancer by promoting the transcription of transcription factors. In terms of mechanisms, RELA and STATs recruit TET3 to prevent DNMT-mediated DNA methylation, thereby maintaining CpG island hypomethylation in the ICAM1 promoter. Therefore, TF occupancy limits DNA methylation and affects ICAM1 expression in breast cancer.
WOS关键词ADHESION MOLECULE-1 ICAM-1 ; GENE-EXPRESSION ; BINDING ; LANDSCAPE ; BROWSER ; ALPHA
资助项目Science and Technology Innovation Action Plan of the Science and Technology Commission of Shanghai Municipality[23Y11920700]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:001506867800003
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/318368]  
专题中国科学院上海药物研究所
通讯作者Fu, Zhengwei; Wu, Chunyu
作者单位1.Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Breast Surg Integrated Tradit & Western Med, Shanghai 200032, Peoples R China
2.Shanghai Univ Tradit Chinese Med, Shanghai TCM Integrated Hosp, Dept Peripheral Vasc, Shanghai 200082, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Metab Dis Res Ctr, Shanghai 201203, Peoples R China
4.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Mingcang,Zhou, Ying,Fu, Zhengwei,et al. Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2025,57(5):818-833.
APA Chen, Mingcang,Zhou, Ying,Fu, Zhengwei,&Wu, Chunyu.(2025).Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,57(5),818-833.
MLA Chen, Mingcang,et al."Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 57.5(2025):818-833.

入库方式： OAI收割

来源：上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。