Analysis of ligustrazine covalent cyclodextrin frameworks in bioinformatics and network pharmacology-based acute lung injury treatment
文献类型：期刊论文
| 作者 | Wu, Di3,4,5; Wang, Xiao Le2; Jia, Yu4; He, Si Yu1; Gao, Ya Ting3,4,5; Yang, Qin Jun3,4; Ding, Huan Zhang3,4,5; Liu, Tong4; Shi, Meng Yao4; Zhang, Ji Wen1 |
| 刊名 | ARABIAN JOURNAL OF CHEMISTRY
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| 出版日期 | 2025-04-01 |
| 卷号 | 18期号:4页码:12 |
| 关键词 | Acute lung injury Bioinformatics Covalent cyclodextrin frameworks Ligustrazine Pulmonary drug delivery |
| ISSN号 | 1878-5352 |
| DOI | 10.25259/AJC_219_2024 |
| 通讯作者 | Zhu, Jie(janezhutcm@foxmail.com) ; Li, Ze Geng(ahzyfb@sina.com) |
| 英文摘要 | Acute lung injury (ALI) is a grave and potentially fatal acute inflammatory condition. Ligustrazine (LIG), an active ingredient in traditional Chinese medicine (TCM), has been proven to inhibit ALI oxidative stress and inflammatory responses; however, its mechanism of ALI treatment remains unclear. We investigated the molecular mechanism of LIG covalent cyclodextrin backbone (LIG-OC-COF) granules in ALI treatment. Network pharmacology identified 16 potential LIG targets, including BCL2L1, JAK2, CDK2, HIF1A, and CCNA2. The Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis suggested that these points were involved in the Janus kinase/signal transducer and activator of transcription (JAK/STATs) signaling pathway. The results from the molecular docking further confirmed the stable binding affinity between target proteins and LIG. In vivo experiments revealed that LIG downregulated the expression of pro-inflammatory factors (i.e., Tumor Necrosis Factor-alpha (TNF-alpha), Interleukin - 1 beta (IL-1 beta), and Interleukin - 6 (IL-6); P < 0.0001) and upregulated the expression of the anti-inflammatory factor (i.e., IL-10; P < 0.0001) in the serum of ALI rat models. This effectively alleviated the apoptosis of ALI lung cells (P < 0.0001) and downregulated the mRNA expression of the aforementioned key targets (P < 0.0001) and the related proteins in the JAK2/STAT3 signaling pathway (P < 0.0001). The inhalation of LIG - covalent cyclodextrin frameworks (LIG-OC-COF) may exert its therapeutic effect by modulating the expression of key target molecules. LIG exhibits an anti-inflammatory and antiapoptotic effect on lung tissues by regulating the BCL2L1, JAK2, CDK2, HIF1A, and CCNA2 molecules and affecting the activation of the JAK/STAT signaling pathway. LIG-OC-COF can enhance these changes. LIG-OCCOF) granules targeting lung delivery of LIG is an effective ALI treatment. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; CD-MOF ; PROLIFERATION ; INFLAMMATION ; INHIBITION ; JAK2/STAT3 ; PI3K/AKT |
| 资助项目 | National Key R&D Program of China[2020YFE0201700] ; National Natural Science Foundation of China ; Joint Fund for Regional Innovation and Development[U20A20398] ; Natural Science Foundation Project of Anhui Province[2208085QH264] ; Anhui University Collaborative Innovation Project, China[GXXT-2020-025] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001506234100002 |
| 出版者 | SCIENTIFIC SCHOLAR LLC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318371]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, Jie; Li, Ze Geng |
| 作者单位 | 1.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Jiangxi Univ Chinese Med, Affiliated Hosp, Nanchang, Peoples R China 3.Anhui Prov Key Lab Applicat & Transformat Tradit C, Hefei, Peoples R China 4.Anhui Univ Chinese Med, Hefei, Peoples R China 5.Anhui Univ Chinese Med, Affiliated Hosp 1, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Di,Wang, Xiao Le,Jia, Yu,et al. Analysis of ligustrazine covalent cyclodextrin frameworks in bioinformatics and network pharmacology-based acute lung injury treatment[J]. ARABIAN JOURNAL OF CHEMISTRY,2025,18(4):12. |
| APA | Wu, Di.,Wang, Xiao Le.,Jia, Yu.,He, Si Yu.,Gao, Ya Ting.,...&Li, Ze Geng.(2025).Analysis of ligustrazine covalent cyclodextrin frameworks in bioinformatics and network pharmacology-based acute lung injury treatment.ARABIAN JOURNAL OF CHEMISTRY,18(4),12. |
| MLA | Wu, Di,et al."Analysis of ligustrazine covalent cyclodextrin frameworks in bioinformatics and network pharmacology-based acute lung injury treatment".ARABIAN JOURNAL OF CHEMISTRY 18.4(2025):12. |
入库方式： OAI收割
来源：上海药物研究所
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