Trpv1-lineage neuron-expressing Kcnq4 channel modulates itch sensation in mice
文献类型：期刊论文
| 作者 | Wang, Qiong3,4; Zhao, Guodun2; Ding, Huijuan2; Wang, Zihan3,4; Wu, Jianwei1; Huang, Han1; Cao, Liang5; Wang, Hongli1; Gao, Zhaobing3,4 ; Feng, Jing2,3,4
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| 刊名 | PAIN
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| 出版日期 | 2025-07-01 |
| 卷号 | 166期号:7页码:1475-1486 |
| 关键词 | Itch Kcnq4 Neuronal excitability Trpv1-lineage neuron |
| ISSN号 | 0304-3959 |
| DOI | 10.1097/j.pain.0000000000003479 |
| 通讯作者 | Feng, Jing(fengjing@simm.ac.cn) |
| 英文摘要 | Voltage-gated potassium channel subfamily q member 4 (Kcnq4) is predominantly expressed by hair cells and auditory neurons and regulates the neuronal excitability in the auditory pathway. Although it is further detected in myelinated large-diameter dorsal root ganglia (DRG) neurons in the periphery, the expression and function of Kcnq4 channel in nociceptors remains unknown. Here we showed that Kcnq4 is substantially expressed by unmyelinated small-diameter DRG neurons in both human and mouse. In spite of a dispensable role in acute pain and chronic skin inflammation, Kcnq4 is specifically involved in the regulation of scratching behavior through controlling action potential firing properties, evidenced by the increased neuronal excitability in small-diameter DRG neurons isolated from Kcnq4 deficient mice. Moreover, genetic ablation of Kcnq4 in Trpv1-positive neurons exacerbates both acute and chronic itch behavior in mice. Taken together, our results uncover a functional role of Trpv1-lineage neuron-expressing Kcnq4 channel in the modulation of itch-specific neuronal excitation in the periphery. |
| WOS关键词 | POTASSIUM CHANNELS ; SENSORY NEURONS ; K+ CHANNELS ; HAIR-CELLS ; PAIN ; ACTIVATION ; RETIGABINE ; RESPONSES ; PATHWAY |
| 资助项目 | National Natural Science Foundation of China |
| WOS研究方向 | Anesthesiology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001510649900001 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318404]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Feng, Jing |
| 作者单位 | 1.Fudan Univ, Huashan Hosp, Dept Orthoped, Shanghai, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai, Peoples R China 5.Tangdu Hosp, Dept Chinese Med, Xian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qiong,Zhao, Guodun,Ding, Huijuan,et al. Trpv1-lineage neuron-expressing Kcnq4 channel modulates itch sensation in mice[J]. PAIN,2025,166(7):1475-1486. |
| APA | Wang, Qiong.,Zhao, Guodun.,Ding, Huijuan.,Wang, Zihan.,Wu, Jianwei.,...&Feng, Jing.(2025).Trpv1-lineage neuron-expressing Kcnq4 channel modulates itch sensation in mice.PAIN,166(7),1475-1486. |
| MLA | Wang, Qiong,et al."Trpv1-lineage neuron-expressing Kcnq4 channel modulates itch sensation in mice".PAIN 166.7(2025):1475-1486. |
入库方式： OAI收割
来源：上海药物研究所
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