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Catalytic system-controlled divergent reactions of pyrazolidinones with 3-alkynyl-3-hydroxyisoindolinones to construct diversified nitrogen-containing heterocyclic scaffolds

文献类型：期刊论文

作者Zhang, Zhenwei2,3,4; Zhang, Xiaoxue1,2,3; Wang, Hao2,3; Xie, Geyao2,3,4; Zhou, Yu1,2,3,4
刊名RSC ADVANCES
出版日期2025-06-23
卷号15期号:27页码:21872-21878
DOI10.1039/d5ra01992c
通讯作者Zhang, Zhenwei(zhangzhenwei@ucas.ac.cn) ; Zhou, Yu(zhouyu@simm.ac.cn)
英文摘要A catalytic system-controlled divergent reaction was reported to construct three distinct nitrogen-containing heterocycles from readily available starting materials via a precise chemical bond activation and annulation cascade. Notably, this is the first capture of pyrazolidinones and propargyl alcohols to construct tetrahydropyrimidinones via selective N-N bond activation and to generate previously unreported 3-acylindoles. This protocol demonstrates a broad substrate scope, moderate to good yields, and valuable transformations, laying a robust foundation for drug discovery applications.
WOS关键词ANNULATION
资助项目National Natural Science Foundation of China[82173656] ; National Natural Science Foundation of China[82373709] ; National Natural Science Foundation of China[82151219] ; National Natural Science Foundation of China[SYS202205] ; Shandong Laboratory Program[2023M730821] ; China Postdoctoral Science Foundation
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001516635700001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/318483]  
专题中国科学院上海药物研究所
通讯作者Zhang, Zhenwei; Zhou, Yu
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Dev Ctr, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Zhenwei,Zhang, Xiaoxue,Wang, Hao,et al. Catalytic system-controlled divergent reactions of pyrazolidinones with 3-alkynyl-3-hydroxyisoindolinones to construct diversified nitrogen-containing heterocyclic scaffolds[J]. RSC ADVANCES,2025,15(27):21872-21878.
APA Zhang, Zhenwei,Zhang, Xiaoxue,Wang, Hao,Xie, Geyao,&Zhou, Yu.(2025).Catalytic system-controlled divergent reactions of pyrazolidinones with 3-alkynyl-3-hydroxyisoindolinones to construct diversified nitrogen-containing heterocyclic scaffolds.RSC ADVANCES,15(27),21872-21878.
MLA Zhang, Zhenwei,et al."Catalytic system-controlled divergent reactions of pyrazolidinones with 3-alkynyl-3-hydroxyisoindolinones to construct diversified nitrogen-containing heterocyclic scaffolds".RSC ADVANCES 15.27(2025):21872-21878.

入库方式： OAI收割

来源：上海药物研究所

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