Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration
文献类型：期刊论文
| 作者 | Li, Jie4,5; Guo, Yuhua3; Liu, Yan2; Gao, Qingfang2; Wang, Siwen3; Wu, Li3,4; Wang, Caifen2,3; Ren, Xiaohong1,3; Zhang, Jiwen3,4
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| 刊名 | PHARMACEUTICS
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| 出版日期 | 2025-06-17 |
| 卷号 | 17期号:6页码:17 |
| 关键词 | mometasone furoate cyclodextrin metal-organic framework nasal powder spray three-dimensional biomimetic model of the human nasal cavity |
| DOI | 10.3390/pharmaceutics17060788 |
| 通讯作者 | Zhang, Jiwen(jwzhang@simm.ac.cn) |
| 英文摘要 | Background/Objectives: Mometasone furoate (MF) is a topical corticosteroid used to reduce allergic and inflammation symptoms. In this study, MF was incorporated into the hydrophobic cavities of gamma-cyclodextrin metal-organic frameworks (CD-MOFs) to prepare MF@MOF powders for nasal delivery. Methods: MF@MOF particles were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and thermogravimetry. A transparent biomimetic model of the human nasal cavity was produced by 3D printing and used to evaluate intra-nasal depositions patterns. Results: Drug loading was optimized by incubating MF with a CD-MOF at a ratio of 4% for 1 h at 40 degrees C, and the cubic morphology and particle size of the nanoparticles were not altered using an incubation method. PXRD and FTIR analyses confirmed the successful loading of MF into the CD-MOF. Using a 3D biomimetic nasal cavity model, a 30 degrees administration angle was found to result in reduced drug accumulation in the nasal vestibule and enhanced deposition in the respiratory and olfactory regions, compared with administration at 45 degrees. Approximately 51% of the drug reached the respiratory zone in the model of the nasal cavity from male subjects, while almost 60% of the drug reached this zone in the model associated with female subjects. Compared with nasal sprays, nasal powder sprays had less deposition in the nasal vestibule and more deposits in the middle and inferior nasal concha. Conclusions: MF@MOF is suitable for intranasal administration. Delivery of MF as a nasal powder shows potential in the treatment of chronic rhinosinusitis. |
| WOS关键词 | SOLID LIPID NANOPARTICLES ; INTRANASAL DELIVERY ; CHRONIC RHINOSINUSITIS ; POWDER ; SYSTEM |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001514978000001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318495]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Jiwen |
| 作者单位 | 1.Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 4.Yangtze Delta Drug Adv Res Inst, Nantong 226126, Peoples R China 5.Shenyang Pharmaceut Univ, Wuya Coll Innovat, Biol & Pharmaceut Sci, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Jie,Guo, Yuhua,Liu, Yan,et al. Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration[J]. PHARMACEUTICS,2025,17(6):17. |
| APA | Li, Jie.,Guo, Yuhua.,Liu, Yan.,Gao, Qingfang.,Wang, Siwen.,...&Zhang, Jiwen.(2025).Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration.PHARMACEUTICS,17(6),17. |
| MLA | Li, Jie,et al."Incorporation of Mometasone Furoate into a Cyclodextrin Metal-Organic Framework to Optimize Nasal Administration".PHARMACEUTICS 17.6(2025):17. |
入库方式： OAI收割
来源：上海药物研究所
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