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Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia

文献类型：期刊论文

作者Wang, Cong22,23,24; Li, Zhi20,21; Zhu, Xiao19; Sun, Wanbing16,17,18; Ding, Yue15; Duan, Wenjia14; Wang, Difei13; Jiang, Yiqing24; Chen, Ming21; Chen, Yuncan12
刊名CELL REPORTS MEDICINE
出版日期2025-06-17
卷号6期号:6页码:28
ISSN号2666-3791
DOI10.1016/j.xcrm.2025.102155
通讯作者Wang, Cong(cong_wang@fudan.edu.cn) ; Xiao, Xiao(xiaoxiao@fudan.edu.cn) ; Zheng, Hairong(hr.zheng@siat.ac.cn) ; Chen, Liang(hschenliang@fudan.edu.cn) ; Li, Cong(congli@fudan.edu.cn) ; Mao, Ying(maoying@fudan.edu.cn)
英文摘要Resective surgery is an effective approach for long-term seizure control in drug-resistant focal epilepsy when the epileptic focue (EF san be accurately elolineated and removed Hewever intraeperative-map--ping of EF with electrocorticography is laborious, time-consuming, and highly vulnerable to the effects of anesthesia. Here, we demonstrated that activated microglia can be reliable biomarkers for EF localiza-tion. Leveraging a newly developed ratiometric Raman nanosensor, ultraHOCIs, we successfully visualize proinflammatory microglia in live epileptic mice, allowing for precise EF delineation without the interfer-ence of anesthesia. Compared to electrocorticography-guided surgery, ultraHOCI-guided surgery results in a substantial 61% reduction in total seizure burden in epileptic mouse models. Notably, ultraHOCIs sprayed on freshly excised human brain tissues can effectively discriminate epileptic regions from non-epileptic tissues with high sensitivity (94.89%) and specificity (93.3%). This work provides an alter-native strategy for delineating the EF intraoperatively, potentially revolutionizing surgery outcomes in ep-ilepsy patients.
WOS关键词OXIDATIVE STRESS ; EPILEPTIFORM
WOS研究方向Cell Biology ; Research & Experimental Medicine
语种英语
WOS记录号WOS:001517368100010
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/318687]  
专题中国科学院上海药物研究所
通讯作者Wang, Cong; Xiao, Xiao; Zheng, Hairong; Chen, Liang; Li, Cong; Mao, Ying
作者单位1.Shanghai Key Lab Brain Funct Restorat & Neural Reg, Shanghai, Peoples R China
2.Chinese Acad Sci, Inst Biomed & Hlth Engn, Shenzhen Inst Adv Technol, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
4.Fudan Univ, Dept Chem, State Key Lab Mol Engn Polymers, Shanghai Key Lab Mol Catalysis & Innovat Mat & iCh, Shanghai, Peoples R China
5.Shanghai Engn Res Ctr Mol Imaging Probes, Shanghai, Peoples R China
6.Fudan Univ, Huashan Hosp, PET Ctr, Shanghai, Peoples R China
7.Vanderbilt Univ, Biomed Engn, Nashville, TN USA
8.Chinese Acad Sci, State Key Lab Transducer Technol, Shanghai Inst Microsyst & Informat Technol, Shanghai, Peoples R China
9.MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China
10.State Key Lab Med Neurobiol, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Cong,Li, Zhi,Zhu, Xiao,et al. Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia[J]. CELL REPORTS MEDICINE,2025,6(6):28.
APA Wang, Cong.,Li, Zhi.,Zhu, Xiao.,Sun, Wanbing.,Ding, Yue.,...&Mao, Ying.(2025).Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia.CELL REPORTS MEDICINE,6(6),28.
MLA Wang, Cong,et al."Ultrabright ratiometric Raman-guided epilepsy surgery by intraoperatively visualizing proinflammatory microglia".CELL REPORTS MEDICINE 6.6(2025):28.

入库方式： OAI收割

来源：上海药物研究所

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