Neuroprotection and Enhanced Learning and Memory Abilities of Steamed American Ginseng (Panax quinquefolium L.) Based on Zebrafish
文献类型：期刊论文
| 作者 | Yang, Yuting7; Liang, Shuyun7; Xu, Mengdan6,7; Liu, Xiaokang3,4,5,7; Guo, Yunlong2; Gong, Jiyu7; Zhao, Liru1; Cai, Guangzhi7 |
| 刊名 | FOOD SCIENCE & NUTRITION
 |
| 出版日期 | 2025-06-01 |
| 卷号 | 13期号:6页码:17 |
| 关键词 | learning and memory
neuroprotection
|
| ISSN号 | 2048-7177 |
| DOI | 10.1002/fsn3.70369 |
| 通讯作者 | Zhao, Liru(15281455@qq.com) ; Cai, Guangzhi(caigz@ccucm.edu.cn) |
| 英文摘要 | American ginseng (Panax quinquefolius L.) exhibits multiple pharmacological properties, including anti-inflammatory, antioxidant, and neuroprotective effects. In 2023, it was officially approved as a dual-purpose substance for both medicinal and food applications, establishing it as a scientifically validated ingredient for functional foods and health supplements. We extracted total saponins (AGTS0-AGTS9) from American ginseng subjected to different steaming-drying cycles to explore how the steaming process affects saponin composition and neuroprotective activity. Using ultra-high-performance liquid chromatography coupled with quadrupole Orbitrap mass spectrometry (UHPLC-Q-Orbitrap/MS) technology, 35 types of ginsenosides were identified from AGTS0-AGTS9. With increasing steaming cycles, the original ginsenoside content decreased, while the rare ginsenoside content gradually increased. During steaming, ginsenosides undergo deglycosylation, hydrolysis, and acetylation, transforming into rare ginsenosides. We employed two models-neuronal injury in transgenic zebrafish larvae and cognitive impairment in wild-type AB adults, both induced by AlCl3-to assess the neuroprotective effects of AGTS0-AGTS9 and the memory-enhancing potential of AGTS5, respectively. Results showed that AGTS4, AGTS5, and AGTS6 markedly increased the neuronal fluorescence area and intensity in larvae, reduced acetylcholinesterase (AChE), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) levels in larval tissues, while elevating acetylcholine (ACh), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activities. AGTS5 exhibited the most potent neuroprotective activity. In adult zebrafish, AGTS5 significantly improved locomotor performance in the Novel Tank Test (NTT) and T-maze, increased Nissl body counts in the brain, reduced AChE activity and MDA/TNF-alpha/IL-6 levels, and enhanced ACh, SOD, GSH-Px, and CAT content. These findings demonstrate that AGTS5 holds promise as a functional food or nutritional supplement for neuroprotection and cognitive enhancement. |
| WOS关键词 | ALZHEIMERS-DISEASE ; GINSENOSIDES ; RG3 ; EXPRESSION ; EXTRACT ; MARKERS ; HEALTH |
| 资助项目 | Jilin Provincial Key Research and Development Plan Project ; [20240305014YY] |
| WOS研究方向 | Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001517193700017 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318693]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, Liru; Cai, Guangzhi |
| 作者单位 | 1.Jilin Inst Biol, Changchun, Peoples R China 2.Changchun Univ Chinese Med, Jilin Ginseng Acad, Changchun, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 4.Nanjing Univ Nat Herbs, Sch Chinese Mat Med, Nanjing, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai, Peoples R China 6.First Peoples Hosp Zhengzhou, Zhengzhou, Peoples R China 7.Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yuting,Liang, Shuyun,Xu, Mengdan,et al. Neuroprotection and Enhanced Learning and Memory Abilities of Steamed American Ginseng (Panax quinquefolium L.) Based on Zebrafish[J]. FOOD SCIENCE & NUTRITION,2025,13(6):17. |
| APA | Yang, Yuting.,Liang, Shuyun.,Xu, Mengdan.,Liu, Xiaokang.,Guo, Yunlong.,...&Cai, Guangzhi.(2025).Neuroprotection and Enhanced Learning and Memory Abilities of Steamed American Ginseng (Panax quinquefolium L.) Based on Zebrafish.FOOD SCIENCE & NUTRITION,13(6),17. |
| MLA | Yang, Yuting,et al."Neuroprotection and Enhanced Learning and Memory Abilities of Steamed American Ginseng (Panax quinquefolium L.) Based on Zebrafish".FOOD SCIENCE & NUTRITION 13.6(2025):17. |
入库方式： OAI收割
来源：上海药物研究所
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