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Site-Selective α-Alkoxylation of Iodonium Ylides with Alcohols via Ruthenium Catalysis

文献类型：期刊论文

作者Shi, Sijia3,4; Liu, Yaxi2,4; Cao, Tian4; Nian, Yong3; Wu, Xiaowei1,2,4
刊名ORGANIC LETTERS
出版日期2025-06-25
卷号27期号:26页码:7253-7260
ISSN号1523-7060
DOI10.1021/acs.orglett.5c02146
通讯作者Nian, Yong(ynian@njucm.edu.cn) ; Wu, Xiaowei(wuxiaowei@simm.ac.cn)
英文摘要Herein, we report an efficient ruthenium-catalyzed alpha-alkoxylation of structurally diverse iodonium ylides with a wide range of primary, secondary, and tertiary alcohols under mild conditions. This strategy provides a versatile platform for the synthesis of diverse 3-alkoxylated 4-hydroxycoumarins and related analogues. The reaction exhibits high site-selectivity, a wide substrate scope, good functional group tolerance, and scale-up synthesis. Additionally, this work not only expands the application scope of hypervalent iodine reagents but also offers a practical and safer alternative to diazo compounds for C-O bond formation while broadening substrate scope.
WOS关键词O-H INSERTION ; EFFICIENT APPROACH ; BONDS ; INDOLES
资助项目National Natural Science Foundation of China[2023YFC2308200] ; National Key R&D Program of China[82404416] ; National Key R&D Program of China[82204192] ; National Natural Science Foundation of China[BK20220471] ; Natural Science Foundation of Jiangsu Province[XPT82204192] ; Nanjing University of Chinese Medicine[SYS202205] ; Shandong Laboratory Program[CXTD2023009] ; Zhongshan Science and Technology Bureau
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001517964900001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/318699]  
专题中国科学院上海药物研究所
通讯作者Nian, Yong; Wu, Xiaowei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Dev Ctr, Shanghai 201203, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China
4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Sijia,Liu, Yaxi,Cao, Tian,et al. Site-Selective α-Alkoxylation of Iodonium Ylides with Alcohols via Ruthenium Catalysis[J]. ORGANIC LETTERS,2025,27(26):7253-7260.
APA Shi, Sijia,Liu, Yaxi,Cao, Tian,Nian, Yong,&Wu, Xiaowei.(2025).Site-Selective α-Alkoxylation of Iodonium Ylides with Alcohols via Ruthenium Catalysis.ORGANIC LETTERS,27(26),7253-7260.
MLA Shi, Sijia,et al."Site-Selective α-Alkoxylation of Iodonium Ylides with Alcohols via Ruthenium Catalysis".ORGANIC LETTERS 27.26(2025):7253-7260.

入库方式： OAI收割

来源：上海药物研究所

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