Human gut Bifidobacterium longum subsp. suillum is enriched in vitro by a pectic polysaccharide isolated from the flowers of Lilium lancifolium
文献类型：期刊论文
| 作者 | Li, Meixia3,5; Liu, Renjie3,5; Wang, Tao4; Duo, Lana5,6; Chen, Guo5; Mao, Mengfei3,5; Sun, Yue4; Li, Yun3,5; Cai, Simin2,5; Zhou, Wanqi5,7,8 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2025-09-15 |
| 卷号 | 364页码:14 |
| 关键词 | Polysaccharides Lilium lancifolium Human gut microbiota Bifidobacterium longum subsp. suillum |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2025.123772 |
| 英文摘要 | Although pectins have been explored widely, knowledge of their effects on the gut microbiota is lacking owing their complex structure. The aim of this study was to investigate whether pectin enriched gut microbes in vitro. To address this, a homogeneous RG-I like pectin, L01-B1, with a molecular weight of 43.9 kDa was extracted from the flowers of Lilium lancifolium. Structural analysis revealed that L01-B1 contained rhamnose, glucuronic acid, galacturonic acid, galactose, and arabinose in a molar ratio of 13.4: 1.8: 11.1: 37.2: 36.5. The backbone of L01-B1 was composed of 1, 6-(3-Galp, 1, 4-a-GalpA, and 1, 2-a-Rhap, whereas the branches included 1, 5-a-Araf, 1, 4-(3-Galp, and T-(3-GlcpA attached to C-4 of rhamnose, and 1, 3-(3-Galp and T-(3-Galp linked to C-3 of galactose. L01-B1 altered the composition of human gut microbiota in vitro and increased the abundance of Bifidobacterium longum. Furthermore, Bifidobacterium longum subsp. suillum strain DK001 was isolated and identified from human feces. The DK001 genome was found to be circular with a genome size of approximately 2.4 M. Notably, L01-B1 might possibly be degraded by two kinds of enzymes and change the metabolism of human gut microbiota. Overall, these findings provide insights into intervention strategies that target Bifidobacterium longum. |
| WOS关键词 | METABOLISM ; BACTERIA ; ARABINOGALACTAN ; PURIFICATION ; BIOACTIVITY ; MICROBIOTA |
| 资助项目 | Zhongshan Municipal Bureau of Science and Technology ; National Natural Science Foundation of China for Young Scholars[82205109] ; Guangzhou Science and Technology Bureau Basic and Applied Basic Research Project[2025A04J3690] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001499253000001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318183]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lai, Haibiao; Ding, Kan |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, SSIP Healthcare & Med Demonstrat Zone, Zhongshan 528400, Guangdong, Peoples R China 2.Henan Univ, Sch Pharm, Kaifeng 475004, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Guangzhou Univ Tradit Chinese Med, Zhongshan Hosp Tradit Chinese Med, Zhongshan 528401, Peoples R China 5.Chinese Acad Sci, Carbohydrate Based Drug Res Ctr, CAS Key Lab Receptor Res, State Key Lab Drug Res,Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210029, Jiangsu, Peoples R China 7.Lingang Lab, Shanghai, Peoples R China 8.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Meixia,Liu, Renjie,Wang, Tao,et al. Human gut Bifidobacterium longum subsp. suillum is enriched in vitro by a pectic polysaccharide isolated from the flowers of Lilium lancifolium[J]. CARBOHYDRATE POLYMERS,2025,364:14. |
| APA | Li, Meixia.,Liu, Renjie.,Wang, Tao.,Duo, Lana.,Chen, Guo.,...&Ding, Kan.(2025).Human gut Bifidobacterium longum subsp. suillum is enriched in vitro by a pectic polysaccharide isolated from the flowers of Lilium lancifolium.CARBOHYDRATE POLYMERS,364,14. |
| MLA | Li, Meixia,et al."Human gut Bifidobacterium longum subsp. suillum is enriched in vitro by a pectic polysaccharide isolated from the flowers of Lilium lancifolium".CARBOHYDRATE POLYMERS 364(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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