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A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative colitis therapy

文献类型：期刊论文

作者Wu, Yueqian3,4; Jiang, Yuting3,4; He, Yihao3,4; Luo, Yanli3; Gu, Zhiwen3,4; Xiu, Yanfeng4; Wang, Bing2,4; Huang, Yongzhuo1,3
刊名INTERNATIONAL JOURNAL OF PHARMACEUTICS
出版日期2025-06-10
卷号678页码:13
关键词Ulcerative colitis Patchouli oil Paeoniflorin Bigel Oral delivery
ISSN号0378-5173
DOI10.1016/j.ijpharm.2025.125706
英文摘要Bigel, formed by high-speed shearing of hydrogel and oleogel, is suited to deliver both lipophilic and hydrophilic active compounds. Patchouli oil and paeoniflorin, despite their potential in treating ulcerative colitis, face challenges due to patchouli oil's poor aqueous solubility and paeoniflorin's high solubility but low permeability. In this study, we developed an oral colon-targeted bigel system to co-deliver patchouli oil and paeoniflorin for treating ulcerative colitis. Patchouli oil served as both a therapeutic agent and an oil phase (excipient). The bigel system enhanced mechanical stability, prolonging retention at the colon and enabling effective colon-targeted drug delivery. Compared to oleogel, bigel significantly alleviated symptoms in DSS-induced colitis in mice, reduced inflammatory cytokine release, repaired intestinal mucosal damage, and regulated immune cell populations in the gut. The combination of patchouli oil and paeoniflorin in the bigel exerted a synergistic effect on ulcerative colitis treatment. This work underscores the efficacy of bigel in delivering a combination of hydrophilic and lipophilic drugs, offering a novel strategy for enhanced drug delivery in ulcerative colitis. It also provides a delivery platform technology for volatile oils.
WOS关键词KONJAC GLUCOMANNAN ; SYSTEMS
资助项目Program of the National Natural Science Foundation of China[82341232] ; Shanghai Committee of Science and Technology of China[22S21902900] ; Natural Science Foundation of Shanghai Municipal[24ZR1477500] ; Future Network of the International Partnership Program of the Chinese Academy of Sciences[083GJHZ2023012FN] ; CAS President's International Fellowship Initiative[2024VBB0004] ; Department of Science and Technology of Guangdong Province (High-level Innovative Research Institute)[2021B0909050003] ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:001498346000002
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/318189]  
专题新药研究国家重点实验室
通讯作者Xiu, Yanfeng; Wang, Bing; Huang, Yongzhuo
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
2.Shanghai Jiao Tong Univ, State Key Lab Syst Med Canc, Shanghai Canc Inst, Renji Hosp,Sch Med, Shanghai, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Yueqian,Jiang, Yuting,He, Yihao,et al. A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative colitis therapy[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2025,678:13.
APA Wu, Yueqian.,Jiang, Yuting.,He, Yihao.,Luo, Yanli.,Gu, Zhiwen.,...&Huang, Yongzhuo.(2025).A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative colitis therapy.INTERNATIONAL JOURNAL OF PHARMACEUTICS,678,13.
MLA Wu, Yueqian,et al."A bigel co-delivering highly hydrophilic and hydrophobic natural compounds for enhanced ulcerative colitis therapy".INTERNATIONAL JOURNAL OF PHARMACEUTICS 678(2025):13.

入库方式： OAI收割

来源：上海药物研究所

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