Dehydrogenated and Aromatized ent-Cleistanthane Diterpenoids From the Roots of Glochidion philippicum
文献类型：期刊论文
| 作者 | Yao, Yang1,2; Li, Chong-Xian2; Duan, Ya-Nan1; Zhou, Bin1; Li, Jing-Ya1 ; Fan, Yao-Yue1; Yue, Jian-Min1,2
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| 刊名 | CHEMISTRY & BIODIVERSITY
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| 出版日期 | 2025-06-03 |
| 页码 | 8 |
| 关键词 | DGK zeta inhibitory
|
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202501481 |
| 英文摘要 | The first comprehensive phytochemical investigation of Glochidion philippicum roots resulted in the isolation and characterization of seven new ent-cleistanthane-type diterpenoids, glochiphenols A-G (1-7), along with two known analogs (8 and 9). Compounds 1-6 all feature a rare alkynyl group, with 1-3 representing highly aromatized 20-nor-ent-cleistanthane diterpenoids. Their structures were elucidated by comprehensive spectroscopic analysis, and absolute configurations were established via electronic circular dichroism (ECD) calculations. Notably, bioactivity assays revealed that compounds 1 and 7 display potent inhibitory effects against DGK zeta with IC50 values of 1.19 and 1.28 mu M, respectively. |
| WOS关键词 | DIACYLGLYCEROL KINASE ; ROLES |
| 资助项目 | National Key Research and Development Program of China[2023YFE0206100] ; National Natural Science Foundation of China[22237007] ; Taishan Scholars Program[tsqn202408315] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001500834800001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318249]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Fan, Yao-Yue; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yao, Yang,Li, Chong-Xian,Duan, Ya-Nan,et al. Dehydrogenated and Aromatized ent-Cleistanthane Diterpenoids From the Roots of Glochidion philippicum[J]. CHEMISTRY & BIODIVERSITY,2025:8. |
| APA | Yao, Yang.,Li, Chong-Xian.,Duan, Ya-Nan.,Zhou, Bin.,Li, Jing-Ya.,...&Yue, Jian-Min.(2025).Dehydrogenated and Aromatized ent-Cleistanthane Diterpenoids From the Roots of Glochidion philippicum.CHEMISTRY & BIODIVERSITY,8. |
| MLA | Yao, Yang,et al."Dehydrogenated and Aromatized ent-Cleistanthane Diterpenoids From the Roots of Glochidion philippicum".CHEMISTRY & BIODIVERSITY (2025):8. |
入库方式： OAI收割
来源：上海药物研究所
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