The glymphatic system was impaired in spontaneously hypertensive rats
文献类型：期刊论文
| 作者 | Xia, Yong5; Lyu, Cui4; Chen, Pengyu5; Jiang, Yuanpeng2,3; Qu, Chunrong3; Lyu, Xinyue5; Cheng, Zhen2,3; Gao, Bo1,5 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2025-05-26 |
| 卷号 | 15期号:1页码:12 |
| 关键词 | Hypertension Glymphatic system AQP4 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/s41598-025-02054-3 |
| 英文摘要 | Hypertension is a clinical syndrome characterized by elevated systemic arterial blood pressure, which can be accompanied by functional impairment of or organic damage to the heart, brain, kidney and other organs. Hypertensive emergencies occur when significant increases in blood pressure result in persistent target organ damage. Hypertensive encephalopathy is a rare hypertensive emergency. Glymphatic system dysfunction is significantly correlated with the occurrence and development of hypertensive encephalopathy. We found that SHRs had a longer duration of peak contrast intensity and a slower clearance of contrast in the brain compared with WKY rats. Of note, in SHRs, there was a clear difference in contrast signal intensity between the hippocampus and the aqueduct. The results of cluster analysis showed that shr and WKY rats exhibited different patterns of voxel clustering. Progressively expanding brain clusters were observed from the posterior part of the brain near the cisterna magna (CM) to the anterior part of the brain, olfactory bulb, and dorsal cortical areas. In addition, shr showed a significant peak delay within some clusters and a slower rate of signal decay with time. Ex vivo imaging of ISF efflux showed that ISF efflux was also significantly reduced in shr. In vitro studies have shown decreased AQP4 expression in the brainstem and olfactory bulb of shr, accompanied by extensive astrogliosis, which may affect CSF circulation.Our study highlights the changes in glymphatic system function in a hypertension model and provides an important theoretical basis for further elucidating the mechanisms underlying the development and progression of hypertensive encephalopathy. |
| WOS关键词 | INTERSTITIAL FLUID ; ARTERIAL PULSATION ; ASSOCIATION ; HIPPOCAMPUS ; AQUAPORIN-4 ; PATHWAY |
| 资助项目 | National Natural Science Foundation of China[81871333] ; Guizhou Province 7th Thousand Innovational and Enterprising Talents[GZQ202007086] ; The 2020 Innovation Group Project of Guizhou Province Educational Commission[KY[2021]017] ; Guizhou Province Science & Technology Project[[2020]4Y159] ; Guizhou Province Science & Technology Innovation Talent Team[CXTD[2022]006] ; Discipline Leading Talent of The Affiliated Hospital of Guizhou Medical University[gyfyxkrc-2023-04] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001496076300034 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318264]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cheng, Zhen; Gao, Bo |
| 作者单位 | 1.Guizhou Med Univ, Key Lab Brain Imaging, Guiyang, Peoples R China 2.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Guizhou Med Univ, Affiliated Hosp, Dept Psychiat, Guiyang, Peoples R China 5.Guizhou Med Univ, Affiliated Hosp, Dept Radiol, Guiyang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Yong,Lyu, Cui,Chen, Pengyu,et al. The glymphatic system was impaired in spontaneously hypertensive rats[J]. SCIENTIFIC REPORTS,2025,15(1):12. |
| APA | Xia, Yong.,Lyu, Cui.,Chen, Pengyu.,Jiang, Yuanpeng.,Qu, Chunrong.,...&Gao, Bo.(2025).The glymphatic system was impaired in spontaneously hypertensive rats.SCIENTIFIC REPORTS,15(1),12. |
| MLA | Xia, Yong,et al."The glymphatic system was impaired in spontaneously hypertensive rats".SCIENTIFIC REPORTS 15.1(2025):12. |
入库方式： OAI收割
来源：上海药物研究所
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