A prebiotic inulin derivative-containing liposome for oral berberine delivery improves the orthotopic colorectal cancer chemotherapy
文献类型：期刊论文
| 作者 | Xia, Anqi1,7,8; Yuan, Wenhui1,7,8; Xu, Shanshan6; Wu, Ting3,7,8; Yan, Wenlu1,7,8; Cao, Ying2,7,8; Li, Yaping1,4,5,6,7,8 ; Yin, Qi1,4,6,7,8
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| 刊名 | NANOSCALE
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| 出版日期 | 2025-06-26 |
| 卷号 | 17期号:25页码:15448-15463 |
| ISSN号 | 2040-3364 |
| DOI | 10.1039/d5nr01337b |
| 英文摘要 | Berberine hydrochloride (BH), a classic drug for treating acute enteritis, has been found to possess multiple immunoregulatory functions. However, its impact on the chemotherapy of colorectal cancer (CRC) has not been revealed. In addition, a suitable oral delivery system for BH is required to reduce and slow its clearance in the intestines and to improve its bioavailability. In the present work, a BH-loaded hybrid liposome containing a prebiotic inulin derivative, named BLPN, was designed and constructed. BLPN was stable in media simulating the gastrointestinal environment. It showed a bidirectional modulatory effect on immune cells, depending on the BH concentration. After oral administration, BLPN prolonged the retention time of BH in the intestines and blood circulation. In an MC38 orthotopic CRC mouse model, BLPN substantially increased the BH accumulation inside tumors. A chemotherapeutic agent, irinotecan hydrochloride-loaded liposome (ILPS), was also prepared. The combination of BLPN with ILPS activated both innate and adaptive anti-tumor immune cells and promoted the secretion of proinflammatory cytokines, which enhanced the extravasation of ILPS from the blood vessels within the tumor. The combination with BLPN significantly improved the CRC tumor-suppressive effect of ILPS and extended the survival time of tumor-bearing mice. This study provides a potential strategy for improving CRC chemotherapy by combining it with a prebiotic oral delivery system for BH. |
| WOS关键词 | BEVACIZUMAB ; GROWTH ; CELLS |
| 资助项目 | National Natural Science Foundation of China ; Shanghai Advanced Research Institute, Chinese Academy of Sciences, China ; Yantai Institute of Materia Medica[32130058] ; Yantai Institute of Materia Medica[32171315] ; National Natural Science Foundation of China[24J22800600] ; Science and Technology Commission of Shanghai Municipality[SYS202205] ; Shandong Laboratory Program |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001506647300001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318303]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Yaping; Yin, Qi |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China 3.Nanjing Med Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211116, Peoples R China 4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264003, Peoples R China 5.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China 6.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Anqi,Yuan, Wenhui,Xu, Shanshan,et al. A prebiotic inulin derivative-containing liposome for oral berberine delivery improves the orthotopic colorectal cancer chemotherapy[J]. NANOSCALE,2025,17(25):15448-15463. |
| APA | Xia, Anqi.,Yuan, Wenhui.,Xu, Shanshan.,Wu, Ting.,Yan, Wenlu.,...&Yin, Qi.(2025).A prebiotic inulin derivative-containing liposome for oral berberine delivery improves the orthotopic colorectal cancer chemotherapy.NANOSCALE,17(25),15448-15463. |
| MLA | Xia, Anqi,et al."A prebiotic inulin derivative-containing liposome for oral berberine delivery improves the orthotopic colorectal cancer chemotherapy".NANOSCALE 17.25(2025):15448-15463. |
入库方式： OAI收割
来源：上海药物研究所
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