Electron acceptor motif-manipulated NIR-II AIE photosensitizers synergically induce tumor pyroptosis through multimodal image-guided pure type I photodynamic and photothermal therapy
文献类型：期刊论文
| 作者 | Xiang, Chunbai6,8; Liu, Yu5,8; Ding, Qihang2; Jiang, Ting7,8; Li, Chao8; Xiang, Jingjing8; Yang, Xing8; Wang, Yue8; Yang, Ting8; Tong, Wenxue3,4 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2026 |
| 卷号 | 324页码:14 |
| 关键词 | Type-I photosensitizers Pyroptosis Aggregation-induced emission Immunotherapy |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2025.123490 |
| 英文摘要 | Pyroptosis, a form of programmed cell death, is known for its strong capacity to induce immunogenic cell death (ICD), triggering the release of damage-associated molecular patterns (DAMPs) that amplify cancer immunotherapy. Recently, photocontrolled pyroptosis has emerged as a promising strategy within photodynamic therapy (PDT). Nonetheless, most existing photosensitizers exhibit a reliance on both type I and type II reactive oxygen species (ROS) generation, which not only leads to suboptimal efficacy in hypoxic tumor environments but also limits therapeutic depth and selectivity. In this study, we report a lysosome-targeted aggregation-induced emission (AIE) photosensitizer, PTQ-TPA3, engineered through receptor unit loop fusion and rotor integration via molecular evolution strategies. PTQ-TPA3 uniquely achieves highly efficient pure type I ROS generation, alongside near-infrared-II (NIR-II) fluorescence emission and photothermal conversion properties. Under the guidance of multimodal imaging modalities, including photoacoustic, NIR-II fluorescence, and photothermal imaging, PTQ-TPA3 nanoparticles enable synergistic photodynamic and photothermal therapy to drive robust ICD-mediated phototherapy. Furthermore, PTQ-TPA3 demonstrates exceptional efficacy in hypoxic tumor environments by producing pure type I ROS while leveraging its photothermal effect to induce pyroptosis. This dual mechanism effectively eradicates cancer cells and stimulates systemic antitumor immunity, paving the way for innovative therapeutic strategies. |
| WOS关键词 | CLEAVAGE |
| 资助项目 | National Key Research and Development Program of China[2021YFA0910000] ; National Natural Science Foundation of China[22474152] ; National Natural Science Foundation of China[U2267221] ; Guangdong Provincial Natural Science Foundation[2024A1515010635] ; Shandong Laboratory Program[SYS202205] ; State Key Laboratory of Drug Research[SIMM0120231004] ; Gansu Science and Technology Major Project[23ZDFA014] ; Shenzhen Science and Technology Program[JCYJ20220818101607016] ; China Postdoctoral Science Foundation[2023M743687] ; Guangdong Basic and Applied Basic Research Fund Project[2023A1515110611] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001510745400008 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318383]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Qi; Lu, Zhiyun; Cheng, Zhen; Gong, Ping |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Korea Univ, Dept Chem, Seoul 02841, South Korea 3.Chinese Univ Hong Kong, Fac Med, Ctr Musculoskeletal Aging & Regenerat, Dept Orthopaed & Traumatol, Hong Kong, Peoples R China 4.Chinese Univ Hong Kong, Musculoskeletal Res Lab, Hong Kong, Peoples R China 5.Univ Macau, Fac Hlth Sci, Canc Ctr, Inst Translat Med, Taipa 999078, Macao, Peoples R China 6.Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China 7.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 8.Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangdong Key Lab Nanomed, CAS HK Joint Lab Biomat, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiang, Chunbai,Liu, Yu,Ding, Qihang,et al. Electron acceptor motif-manipulated NIR-II AIE photosensitizers synergically induce tumor pyroptosis through multimodal image-guided pure type I photodynamic and photothermal therapy[J]. BIOMATERIALS,2026,324:14. |
| APA | Xiang, Chunbai.,Liu, Yu.,Ding, Qihang.,Jiang, Ting.,Li, Chao.,...&Gong, Ping.(2026).Electron acceptor motif-manipulated NIR-II AIE photosensitizers synergically induce tumor pyroptosis through multimodal image-guided pure type I photodynamic and photothermal therapy.BIOMATERIALS,324,14. |
| MLA | Xiang, Chunbai,et al."Electron acceptor motif-manipulated NIR-II AIE photosensitizers synergically induce tumor pyroptosis through multimodal image-guided pure type I photodynamic and photothermal therapy".BIOMATERIALS 324(2026):14. |
入库方式： OAI收割
来源：上海药物研究所
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