Diterpenoids and diarylheptanoids from the fruits of Alpinia zerumbet and their anti-inflammatory activity
文献类型：期刊论文
| 作者 | Zhang, Zhenghan6,7,8; Li, Guangqian4,5; Luo, Xin3; Xiao, Fang8; Zhang, Yan2; Tang, Chunping7,8 ; Hu, Bintao7,8; Xie, Zuoquan8; Yao, Sheng4,5,6,8; Ye, Yang1,6,7,8
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2025-07-01 |
| 卷号 | 184页码:10 |
| 关键词 | Alpinia zerumbet Labdane-type diterpenoid Diarylheptanoid Anti-inflammatory ISG pathway TDDFT ECD calculation |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2025.106662 |
| 英文摘要 | A chemical investigation of the fruits of Alpinia zerumbet resulted in the isolation of three undescribed diterpenoids, including an unusual tricyclic dinor-diterpenoid (1) and two labdane-type diterpenoids (2 and 4), a new diarylheptanoid (7), and a new tricyclic pyrone (9), along with four known compounds. Their structures were fully established through a comprehensive analysis involving high-resolution electrospray ionization mass spectrometry (HRESI-MS), IR, 1D and 2D NMR spectroscopic data, single-crystal X-ray diffraction, and TDDFT (time-dependent density functional theory) ECD (electronic circular dichroism) calculations. The antiinflammatory activities of isolated compounds were assessed in stimulator of interferon genes (STING) agonist MSA-2-stimulated human THP1-Dual cells for their inhibitory effects on the interferon-stimulated gene (ISG) pathway. The results showed that compound 5 exhibited remarkable anti-inflammatory effect by significantly inhibiting the expression of IFN-beta, ISG-15, and IL-6 in MSA-2-stimulated human THP1-Dual cells. |
| WOS关键词 | ESSENTIAL OIL ; INVOLVEMENT |
| 资助项目 | National Key Research and Development Program Strategic Scientific and Technological Innovation Cooperation Key Project[2022YFE0203600] ; Ministry of Science and Technology ; National Natural Science Foundation of China[82173696] ; National Natural Science Foundation of China[82373766] ; Guangdong Basic and Applied Basic Research Foundation[2024A1515011348] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2023010] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001509010000002 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318392]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xie, Zuoquan; Yao, Sheng; Ye, Yang |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, Canc Res Ctr, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xian Lin Rd, Nanjing 210023, Jiangsu, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 5.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China 6.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Shanghai Inst Mat Med, China Serbia Belt & Rd Joint Lab Nat Prod & Drug D, Shanghai 201203, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhenghan,Li, Guangqian,Luo, Xin,et al. Diterpenoids and diarylheptanoids from the fruits of Alpinia zerumbet and their anti-inflammatory activity[J]. FITOTERAPIA,2025,184:10. |
| APA | Zhang, Zhenghan.,Li, Guangqian.,Luo, Xin.,Xiao, Fang.,Zhang, Yan.,...&Ye, Yang.(2025).Diterpenoids and diarylheptanoids from the fruits of Alpinia zerumbet and their anti-inflammatory activity.FITOTERAPIA,184,10. |
| MLA | Zhang, Zhenghan,et al."Diterpenoids and diarylheptanoids from the fruits of Alpinia zerumbet and their anti-inflammatory activity".FITOTERAPIA 184(2025):10. |
入库方式： OAI收割
来源：上海药物研究所
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