Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis
文献类型：期刊论文
| 作者 | Yu, Zhouyu3; Zou, Lijia2; Liu, Ruiqi1; Zhang, Xiaoyan3; Cheng, Zhen1; Chen, Si2; Chang, Baisong3 |
| 刊名 | ADVANCED THERAPEUTICS
 |
| 出版日期 | 2025-06-17 |
| 页码 | 13 |
| 关键词 | activatable nanoprobes Janus nanoparticles liver fibrosis NIR-II bioimaging |
| DOI | 10.1002/adtp.202500142 |
| 英文摘要 | Liver fibrosis presents a significant global health challenge due to its potential progression to cirrhosis, liver failure, or hepatocellular carcinoma, highlighting the necessity for precise imaging of fibrosis progression. Here, a straightforward synthesis method is proposed to design bioresponsive nanoprobes capable of achieving high-resolution bioimaging of liver fibrosis. Janus MnO2-coated Ag/Ag2S nanoparticles modified by polyethylene glycol (denoted as jMAP) can inherit both the activatable properties from Ag/Ag2S and MnO2 components in the pathological microenvironment. Multiple lines of evidence supported that overexpressed levels of reactive oxygen species (ROS) in liver fibrosis efficiently transformed jMAP nanoprobes to Ag2S products, activating bright fluorescence in the second near-infrared window (NIR-II, 1000-1700 nm). In addition, the catalase-like and superoxide dismutase-like activities of jMAP probes reduce hypoxia and oxidative stress with a clearance rate of about 73.3% toward ROS, thereby downregulating hypoxia-inducible factor (HIF-1 alpha) and NADPH oxidase-4 (NOX-4) by 49.5% and 47.9%, respectively. Overall, the developed jMAP probes demonstrate impressive diagnostic accuracy, offering transformative prospects for liver fibrosis diagnosis. |
| 资助项目 | National Natural Science Foundation of China ; Natural Science Fund for Distinguished Young Scholars of Hubei Province[2024AFA084] ; Young Top-notch Talent Cultivation Program of Hubei Province, China ; [52373307] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001510457000001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318416]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Chen, Si; Chang, Baisong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Cent South Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Peoples R China 3.Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Zhouyu,Zou, Lijia,Liu, Ruiqi,et al. Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis[J]. ADVANCED THERAPEUTICS,2025:13. |
| APA | Yu, Zhouyu.,Zou, Lijia.,Liu, Ruiqi.,Zhang, Xiaoyan.,Cheng, Zhen.,...&Chang, Baisong.(2025).Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis.ADVANCED THERAPEUTICS,13. |
| MLA | Yu, Zhouyu,et al."Leveraging Activatable Janus Nanoprobes for NIR-II Imaging and Enzyme-Like Activity in Monitoring Liver Fibrosis".ADVANCED THERAPEUTICS (2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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