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Nanohydroxyapatite-Stabilized Pickering-Emulsion-Incorporated Hydrogel Prevents Postoperative Osteosarcoma Recurrence and Promotes Bone Repair

文献类型：期刊论文

作者Zhang, Yi3,4,5,6,7,8; Wang, Yuewei3; Zhang, Xiaofei3; Yue, Lixia3; Yang, Lu3; Lai, Hongchang4,5,6,7,8; Yang, Chunhao3; Huang, Yongzhuo1,2,3
刊名NANO LETTERS
出版日期2025-06-23
卷号25期号:26页码:10487-10496
关键词osteosarcoma injectable hydrogel nanohydroxyapatite Pickering emulsion RANKL inhibitor bone regeneration
ISSN号1530-6984
DOI10.1021/acs.nanolett.5c01949
英文摘要Osteosarcoma (OS) is a highly aggressive malignancy. Current therapies offer limited efficacy, necessitating innovative strategies. This study introduces a novel injectable hydrogel integrated with nanohydroxyapatite (nHAP)-stabilized Pickering emulsions for the local delivery of receptor activator of nuclear factor kappa B ligand inhibitor. We assessed the system's efficacy through cell viability, apoptosis, and migration assays in osteosarcoma cells and evaluated tumor suppression and bone regeneration in a critical-sized skull defect model in mice. Our results indicate that the system significantly induced apoptosis and inhibited migration in osteosarcoma cells. In an animal model, the hydrogel system demonstrated an inhibitory effect on tumor growth, reducing the tumor volume. Furthermore, new bone formation was observed at the skull defect site, suggesting the system's potential for both antitumor activity and the promotion of bone repair. This integrated system offers enhanced antitumor efficacy and bone regeneration capabilities, thus improving OS treatment outcomes.
WOS关键词EXPRESSION ; PECTIN
资助项目National Natural Science Foundation of China ; Shanghai Advanced Research Institute, Chinese Academy of Sciences
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:001514120500001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/318465]  
专题新药研究国家重点实验室
通讯作者Lai, Hongchang; Yang, Chunhao; Huang, Yongzhuo
作者单位1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Shanghai Jiao Tong Univ, Shanghai Key Lab Stomatol, Shanghai 200011, Peoples R China
5.Shanghai Jiao Tong Univ, Natl Clin Res Ctr Oral Dis, Shanghai 200011, Peoples R China
6.Shanghai Jiao Tong Univ, Natl Ctr Stomatol, Shanghai 200011, Peoples R China
7.Shanghai Jiao Tong Univ, Coll Stomatol, Shanghai 200011, Peoples R China
8.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Implant Dent, Shanghai 200011, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Yi,Wang, Yuewei,Zhang, Xiaofei,et al. Nanohydroxyapatite-Stabilized Pickering-Emulsion-Incorporated Hydrogel Prevents Postoperative Osteosarcoma Recurrence and Promotes Bone Repair[J]. NANO LETTERS,2025,25(26):10487-10496.
APA Zhang, Yi.,Wang, Yuewei.,Zhang, Xiaofei.,Yue, Lixia.,Yang, Lu.,...&Huang, Yongzhuo.(2025).Nanohydroxyapatite-Stabilized Pickering-Emulsion-Incorporated Hydrogel Prevents Postoperative Osteosarcoma Recurrence and Promotes Bone Repair.NANO LETTERS,25(26),10487-10496.
MLA Zhang, Yi,et al."Nanohydroxyapatite-Stabilized Pickering-Emulsion-Incorporated Hydrogel Prevents Postoperative Osteosarcoma Recurrence and Promotes Bone Repair".NANO LETTERS 25.26(2025):10487-10496.

入库方式： OAI收割

来源：上海药物研究所

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