Kadcoccinoids A-K, triterpenoids from Kadsura coccinea with PCSK9 expression inhibitory activities
文献类型：期刊论文
| 作者 | Duan, Yelin2,3; Chen, Tong2; Guo, Pengju1,2; Li, Chenyue1,2; Chen, Yihan2,3; Zhang, Mingge2; Yan, Mengkun2; Wang, Wenqiong2; Xuan, Lijiang1,2,3
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| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2025-10-01 |
| 卷号 | 238页码:13 |
| 关键词 | Kadsura coccinea Schisandraceae Lanostane-type triterpenoids Protostane-type triterpenoids PCSK9 |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2025.114584 |
| 英文摘要 | Two undescribed protostane-type triterpenoids (1-2), and nine undescribed lanostane-type triterpenoids (3-11), along with nine known compounds (12-20) were isolated from the stems of Kadsura coccinea. Their chemical structures were elucidated by extensive spectroscopic analyses, Mosher's method, X-ray crystallography, and electronic circular dichroism calculations. Kadcoccinoid A (1) possesses an undescribed 6/6/8-fused carbocyclic core containing a rare bicyclo [4.2.1] nonan-9-one system and proposed plausible biosynthetic pathway. Additionally, kadcoccinoid B (2) significantly decreased PCSK9 protein levels in the medium of HepG2 cells at 10 mu M with an inhibition rate of 78.4 % and increased LDL uptake at 5 and 10 mu M, while compounds 12-14 showed moderate PCSK9 inhibitory activities. |
| WOS关键词 | ABSOLUTE-CONFIGURATIONS ; ACIDS |
| 资助项目 | State Key Laboratory of Drug Research[SIMM1601ZZ-03] ; National Natural Science Foundation of China[82373746] ; Shanghai Municipal Science and Technology Major Project[TM202301L001] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001512996700002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318615]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Wenqiong; Xuan, Lijiang |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Yelin,Chen, Tong,Guo, Pengju,et al. Kadcoccinoids A-K, triterpenoids from Kadsura coccinea with PCSK9 expression inhibitory activities[J]. PHYTOCHEMISTRY,2025,238:13. |
| APA | Duan, Yelin.,Chen, Tong.,Guo, Pengju.,Li, Chenyue.,Chen, Yihan.,...&Xuan, Lijiang.(2025).Kadcoccinoids A-K, triterpenoids from Kadsura coccinea with PCSK9 expression inhibitory activities.PHYTOCHEMISTRY,238,13. |
| MLA | Duan, Yelin,et al."Kadcoccinoids A-K, triterpenoids from Kadsura coccinea with PCSK9 expression inhibitory activities".PHYTOCHEMISTRY 238(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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