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Arabinogalactan-like polysaccharide isolated from the flowers of Dendrobium officinale regulates the gut microbes and promotes vitamin K1, vitamin A, and vitamin B6 products

文献类型：期刊论文

作者Jin, Can6,7; Li, Meixia7; Duo, Lana5; Chen, Huixian1,6; Guo, Xiaozhen7; Li, Saijuan5,7; Wen, Chang4,7; Xie, Cen7; Ding, Kan2,3,4,5,6,7
刊名CARBOHYDRATE POLYMERS
出版日期2025-10-15
卷号366页码:13
关键词Dendrobium officinale Polysaccharide Arabinogalactan Bacteroides spp. Vitamin
ISSN号0144-8617
DOI10.1016/j.carbpol.2025.123660
英文摘要Arabinogalactan (AG) is one ubiquitous feature of plant polysaccharides that may regulate Human Gut Micro-biota (HGM). However, whether AG induces vitamin generation linked to HGM modified by this polysaccharide is still vague. We hypothesize that the gut microbiota possesses the ability to degrade AG, while AG may reshape HGM to produce vitamins. Here, we showed that an AG-like polysaccharide TF112 (Mw 54.7 kDa) was purified from the flowers of Dendrobium officinale. It comprised rhamnose, galacturonic acid, galactose, and arabinose in a molar ratio of 1.00: 1.01: 4.00: 2.55. The backbone was an alternating 1, 2, 4-linked Rha and 1, 4-linked GalA, where the O-4 position of 1, 2, 4-Rha was substituted by three types branches: one as-*1)-Gal-(4-*1)-Gal, another as-*1)-Ara, and the remaining one as arabinogalactan polymers, respectively. We further showed that TF112 can be degraded into monosaccharides and oligosaccharides by Bacteroides spp. Further, we provided evidence that TF112 changed the composition of the gut microbiota of mice and increased the content of vitamin K1, vitamin A, and vitamin B6 in the feces of mice. Overall, our research provides new insights into understanding the crosstalk between AG and HGM linked to vitamin generation.
WOS关键词METABOLISM ; PECTIN ; EXPRESSION
资助项目High-level Innovative Research Institute[32471328] ; Department of Science and Technology of Guangdong Province[2021B0909050003] ; Ninth Batch of Innovative Scientific Research Team Projects from Zhongshan Science and Technology Bureau
WOS研究方向Chemistry ; Polymer Science
语种英语
WOS记录号WOS:001510788400005
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.183/handle/2S10ELR8/318639]  
专题新药研究国家重点实验室
通讯作者Li, Meixia; Ding, Kan
作者单位1.Southern Med Univ, Sch Pharmaceut Sci, 1023 South Shatai Rd, Guangzhou 510515, Guangdong, Peoples R China
2.Henan Univ Chinese Med, Henan Polysaccharide Res Ctr, Zhengzhou 450046, Peoples R China
3.Henan Univ Chinese Med, Acad Chinese Med Sci, Zhengzhou 450046, Peoples R China
4.Zunyi Med Univ, Xuefu West Rd, Zunyi 563000, Guizhou, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, 138 Xianlin Ave, Nanjing 210023, Peoples R China
6.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, SSIP Healthcare & Med Demonstrat Zone, Zhongshan 528400, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, Carbohydrate Based Drug Res Ctr, CAS Key Lab Receptor Res,State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Jin, Can,Li, Meixia,Duo, Lana,et al. Arabinogalactan-like polysaccharide isolated from the flowers of Dendrobium officinale regulates the gut microbes and promotes vitamin K1, vitamin A, and vitamin B6 products[J]. CARBOHYDRATE POLYMERS,2025,366:13.
APA Jin, Can.,Li, Meixia.,Duo, Lana.,Chen, Huixian.,Guo, Xiaozhen.,...&Ding, Kan.(2025).Arabinogalactan-like polysaccharide isolated from the flowers of Dendrobium officinale regulates the gut microbes and promotes vitamin K1, vitamin A, and vitamin B6 products.CARBOHYDRATE POLYMERS,366,13.
MLA Jin, Can,et al."Arabinogalactan-like polysaccharide isolated from the flowers of Dendrobium officinale regulates the gut microbes and promotes vitamin K1, vitamin A, and vitamin B6 products".CARBOHYDRATE POLYMERS 366(2025):13.

入库方式： OAI收割

来源：上海药物研究所

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