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Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKa2 signaling

文献类型：期刊论文

作者Chen, Jianghui10,11; Xiang, Jing10,11; Zhou, Meiyu10,11; Huang, Rongfeng8,9,10,11; Zhang, Jianxin7,10,11; Cui, Yuanting10,11; Jiang, Xiaoqing10,11; Li, Yang10,11; Zhou, Runchao10,11; Xin, Haoran10,11
刊名CELL METABOLISM
出版日期2025-06-03
卷号37期号:6页码:24
ISSN号1550-4131
DOI10.1016/j.cmet.2025.02.007
英文摘要Feeding rhythms regulate exercise performance and muscle energy metabolism. However, the mechanisms regulating adipocyte functions remain unclear. Here, using multi-omics analyses, involving (phospho-)proteomics and lipidomics, we found that day-restricted feeding (DRF) regulates diurnal rhythms of the mitochondrial proteome, neutral lipidome, and nutrient-sensing pathways in mouse gonadal white adipose tissue (GWAT). Adipocyte-specific knockdown of Prkaa2 (the gene encoding AMPKa2) impairs physical endurance. This defect is associated with altered rhythmicity in acyl-coenzyme A (CoA) metabolism-related genes, a loss of rhythmicity in the GWAT lipidome, and circadian remodeling of serum metabolites-in particular, lactate and succinate. We also found that adipocyte Prkaa2 regulates muscle clock genes during DRF. Notably, oral administration of the AMPK activator C29 increases endurance and muscle functions in a time-of-day manner, which requires intact adipocyte AMPKa2 signaling. Collectively, our work defines adipocyte AMPKa2 signaling as a critical regulator of circadian metabolic coordination between fat and muscle, thereby enhancing exercise performance.
WOS关键词CIRCADIAN CLOCK ; INSULIN SENSITIVITY ; TIME ; METABOLISM ; PHOSPHORYLATION ; MICE ; ENDURANCE ; CAPACITY ; PLATFORM ; RHYTHMS
资助项目National Natural Science Foundation of China[32471213] ; National Natural Science Foundation of China[92057109] ; National Natural Science Foundation of China[32400976] ; Noncommunicable Chronic Diseases-National Science and Technology Major Project[2023ZD0507800] ; Chongqing Science Fund for Distinguished Young Scholars[CSTB202 2NSCQ-JQX0009] ; Chongqing Municipal Health Commission[HBRC2 02405] ; Chongqing Technology Innovation and Application Demonstration Key Research and Development Project[CSTB2023TIAD-KPX0061-2] ; Chongqing Talent Program[CQYC20210303360]
WOS研究方向Cell Biology ; Endocrinology & Metabolism
语种英语
WOS记录号WOS:001505238500005
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/318645]  
专题新药研究国家重点实验室
通讯作者Zhang, Zhihui; Li, Min-Dian
作者单位1.PLA, Key Lab High Altitude Med, Chongqing 400038, Peoples R China
2.Minist Educ China, Key Lab Extreme Environm Med, Chongqing 400038, Peoples R China
3.Army Med Univ, Coll High Altitude Mil Med, Dept Pathophysiol, Chongqing 400038, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.LipidALL Technol Co Ltd, Changzhou, Peoples R China
6.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China
7.960th Hosp PLA Joint Serv Support Force, Dept Cardiol, Jinan 250000, Peoples R China
8.Sichuan Univ, West China Hosp 4, Chengdu 610072, Peoples R China
9.Sichuan Univ, West China Sch Publ Hlth, Dept Nutr & Food Hyg, Chengdu 610072, Peoples R China
10.Minist Educ Key Lab Geriatr Cardiovasc & Cerebrova, Key Lab Geriatr Cardiovasc & Cerebrovascular Dis, Chongqing 400038, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Jianghui,Xiang, Jing,Zhou, Meiyu,et al. Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKa2 signaling[J]. CELL METABOLISM,2025,37(6):24.
APA Chen, Jianghui.,Xiang, Jing.,Zhou, Meiyu.,Huang, Rongfeng.,Zhang, Jianxin.,...&Li, Min-Dian.(2025).Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKa2 signaling.CELL METABOLISM,37(6),24.
MLA Chen, Jianghui,et al."Dietary timing enhances exercise by modulating fat-muscle crosstalk via adipocyte AMPKa2 signaling".CELL METABOLISM 37.6(2025):24.

入库方式： OAI收割

来源：上海药物研究所

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