Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply
文献类型：期刊论文
| 作者 | Pan, Chao5,6; Jiang, Xiuxian5,6; Wei, Junchao4,6; Liu, Chang5,6; Zhang, Min5,6; Gao, Chuan3,6; Chen, Rongrong2,6; Yang, Canyu3,6; Wang, Bingqi5,6; Yu, Miaorong5,6 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2025-02-20 |
| 卷号 | 16期号:1页码:17 |
| DOI | 10.1038/s41467-025-57071-7 |
| 英文摘要 | Nutrient competition with indigenous microbes or pathogens presents a significant challenge for oral probiotic efficacy. To address this issue, we develop an ameba-inspired food-carrying strategy (AIFS) by prebinding ginger-derived exosome-like nanoparticles (GELNs) onto probiotics as food depots. AIFS enables probiotics to efficiently and exclusively consume GELNs in situ, even in the presence of competing bacteria. This results in up to 21 times higher uptake efficiency compared to unengineered probiotics, dramatically accelerating probiotic proliferation. Meanwhile, AIFS potentiates probiotics' resistance to multiple GI stressors. In a murine model of colitis, AIFS can improve the abundance of probiotics and inhibit pathogens, maintaining intestinal flora homeostasis. Additionally, it can upregulate the anti-inflammatory IL-10, reduce the proinflammatory IL-1 beta, and repair damaged intestinal mucus. Thereby, AIFS displays potently elevated prophylactic and therapeutic efficacy for colitis mice. This work provides a method for microbial engineering, with broad implications for microbiotherapy and gut health. |
| WOS关键词 | MICROBIOTA ; COLITIS ; DRUG |
| 资助项目 | National Science Fund of Distinguished Young Scholars[82025032] ; National Science Fund of Distinguished Young Scholars[NCTIB2022HS01006] ; Key Research Program of Chinese Academy of Sciences[ZDBS-ZRKJZ-TLC005] ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM0220232001] ; Shanghai Action Plan for Science, Technology and Innovation[23HC1401200] ; China Postdoctoral Science Foundation[2021M703350] ; Shanghai Post-doctoral Excellence Program[2021427] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001509296900019 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318651]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Gan, Yong |
| 作者单位 | 1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Medica, Nanjing, Peoples R China 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Peoples R China 4.Henan Univ, Sch Pharm, Kaifeng, Peoples R China 5.Univ Chinese Acad Sci, Beijing, Peoples R China 6.Shanghai Inst Mat Medica, Chinese Acad Sci, State Key Lab Drug Res Ctr Pharmaceut, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Chao,Jiang, Xiuxian,Wei, Junchao,et al. Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply[J]. NATURE COMMUNICATIONS,2025,16(1):17. |
| APA | Pan, Chao.,Jiang, Xiuxian.,Wei, Junchao.,Liu, Chang.,Zhang, Min.,...&Gan, Yong.(2025).Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply.NATURE COMMUNICATIONS,16(1),17. |
| MLA | Pan, Chao,et al."Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply".NATURE COMMUNICATIONS 16.1(2025):17. |
入库方式： OAI收割
来源：上海药物研究所
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