Dimorpoloids A-D, Three Rearranged Diterpenoids and One Unique Daphnane-Type Diterpenoid from Dimorphocalyx poilanei
文献类型：期刊论文
| 作者 | Chen, Shu-Shuai1,2; Chen, Yu-Han1; Zheng, Cheng-Yu2; Yue, Jian-Min1,2 ; Fan, Yao-Yue1,2
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2025-07-02 |
| 卷号 | 90期号:27页码:9541-9548 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.5c01017 |
| 英文摘要 | The first phytochemical investigation of Dimorphocalyx poilanei led to the isolation and characterization of four novel diterpenoids, namely, dimorpoloids A-D (1-4), along with two biosynthetically related known diterpenoids. Compounds 1 and 2 are rearranged ent-cleistanthane diterpenoids with a 6/7/6-fused tricyclic scaffold. Compound 3 is a rearranged 17-nor-ent-labdane-type diterpenoid, distinguished by a novel tropone ring system in its molecular architecture. Compound 4 represents the first daphnane-type diterpenoid featuring an aromatic C-ring system. Their structures were elucidated by spectroscopic analysis and quantum chemical calculations. Putative biosynthetic pathways for compounds 1-3 are proposed. Compounds 1 and 3-6 exhibited antiadipogenic effects in 3T3-L1 adipocytes, and the most potent compound 6 showed an EC50 value of 3.29 +/- 0.53 mu M. |
| 资助项目 | National Natural Science Foundation of China[2023YFE0206100] ; National Key Research and Development Program of China[22237007] ; National Natural Science Foundation of China[tsqn202408315] ; Taishan Scholars Program[2023690] ; Shanghai Postdoctoral Excellence Program |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001521554800001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318663]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min; Fan, Yao-Yue |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Shu-Shuai,Chen, Yu-Han,Zheng, Cheng-Yu,et al. Dimorpoloids A-D, Three Rearranged Diterpenoids and One Unique Daphnane-Type Diterpenoid from Dimorphocalyx poilanei[J]. JOURNAL OF ORGANIC CHEMISTRY,2025,90(27):9541-9548. |
| APA | Chen, Shu-Shuai,Chen, Yu-Han,Zheng, Cheng-Yu,Yue, Jian-Min,&Fan, Yao-Yue.(2025).Dimorpoloids A-D, Three Rearranged Diterpenoids and One Unique Daphnane-Type Diterpenoid from Dimorphocalyx poilanei.JOURNAL OF ORGANIC CHEMISTRY,90(27),9541-9548. |
| MLA | Chen, Shu-Shuai,et al."Dimorpoloids A-D, Three Rearranged Diterpenoids and One Unique Daphnane-Type Diterpenoid from Dimorphocalyx poilanei".JOURNAL OF ORGANIC CHEMISTRY 90.27(2025):9541-9548. |
入库方式： OAI收割
来源：上海药物研究所
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