NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma
文献类型：期刊论文
| 作者 | Yu, Donghu5,6; Ding, Qihang1; Xiang, Chunbai4; Wang, Danwen3,5,6; Hu, Lei5,6; Wang, Junneng5,6; Qian, Kun2; Cheng, Zhen2; Li, Zhiqiang5,6 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2025-06-20 |
| 卷号 | 19期号:25页码:22900-22913 |
| 关键词 | glioblastoma NIR-II blood-brainbarrier photothermal therapy photodynamic therapy |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.5c01541 |
| 英文摘要 | Glioblastoma (GBM), a highly aggressive and lethal brain tumor, presents a formidable clinical challenge due to its poor prognosis and lack of effective treatment options, underscoring the urgent need for innovative therapeutic strategies. Here, we report a promising phototheranostic platform based on a near-infrared II (NIR-II) organic molecule, MYM, which combines robust fluorescence with potent photothermal and photodynamic therapeutic capabilities. To maximize efficacy, MYM was encapsulated in exosomes derived from 293F cells and further functionalized with the iRGD peptide, enhancing both tumor targeting and penetration of the blood-brain barrier (MYM@iRGD-Exo). In vivo, studies demonstrate that MYM@iRGD-Exo can effectively penetrate the blood-brain barrier and selectively target GBM cells. Upon laser irradiation, it significantly inhibits tumor progression while promoting T-cell infiltration to enhance the immune response. Comprehensive RNA sequencing analyses revealed the activation of immune response pathways, highlighting the potential of this system to modulate antitumor immunity. This study offers an effective approach to glioblastoma therapy by integrating precision-targeted delivery, multimodal imaging, and synergistic therapeutic effects. The findings provide a theranostics platform aimed at overcoming current treatment limitations and improving clinical outcomes for cancer. |
| 资助项目 | National Natural Science Foundation of China[2021BCA143] ; Hubei Province Key Research & Development Program[U2267221] ; National Natural Science Foundation of China[23ZDFA014] ; Gansu Science and Technology Major Project[SIMM0120231004] ; State Key Laboratory of Drug Research[SYS202205] ; Shandong Laboratory Program[XDB0830300] ; Strategic Priority Research Program of the Chinese Academy of Sciences[202106270027] ; China Scholarship Council (CSC) |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001518544700001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/318696]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ding, Qihang; Cheng, Zhen; Li, Zhiqiang |
| 作者单位 | 1.Korea Univ, Dept Chem, Seoul 02841, South Korea 2.Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Wuhan Univ, Dept Radiol, Zhongnan Hosp, Wuhan 430071, Peoples R China 4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangdong Key Lab Nanomed, CAS HK Joint Lab Biomat, Shenzhen 518055, Peoples R China 5.Wuhan Univ, Zhongnan Hosp, Dept Neurosurg, Int Sci & Technol Cooperat Base Res & Clin Tech Br, Wuhan 430071, Peoples R China 6.Wuhan Univ, Zhongnan Hosp, Brain Glioma Ctr, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Donghu,Ding, Qihang,Xiang, Chunbai,et al. NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma[J]. ACS NANO,2025,19(25):22900-22913. |
| APA | Yu, Donghu.,Ding, Qihang.,Xiang, Chunbai.,Wang, Danwen.,Hu, Lei.,...&Li, Zhiqiang.(2025).NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma.ACS NANO,19(25),22900-22913. |
| MLA | Yu, Donghu,et al."NIR-II Engineered Exosome Nanotheranostic Probes for "Oriented Blasting" in Orthotopic Glioblastoma".ACS NANO 19.25(2025):22900-22913. |
入库方式： OAI收割
来源：上海药物研究所
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