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Dialysis Adequacy Sensor With Systematic Error Correction Algorithm for Hemodialysis Machines

文献类型：期刊论文

作者Cao, Xinfang2,3; Wang, Bo2,4; Zhou, Lianqiao2,3; Zhang, Chunke5; Lan, Yuqun2,3; Li, Qinlan2,3; Wang, Shugang5; Cui, Jingqiang5; Cheng, Wensheng5; Wang, Guosheng
刊名IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
出版日期2025
卷号74页码:9
关键词Monitoring Blood Real-time systems Correlation Accuracy Wavelength measurement Systematics Optical sensors Kidney Training Correction algorithm dialysis adequacy sensor (DAS) medical device
ISSN号0018-9456
DOI10.1109/TIM.2025.3590838
通讯作者Wang, Bo(wangbo@imech.ac.cn) ; Su, Yewang(yewangsu@imech.ac.cn)
英文摘要During hemodialysis, real-time monitoring of patients' dialysis adequacy on hemodialysis machines can prevent complications and improve the long-term survival rate of patients. However, current online monitoring technologies are limited by various shortcomings, such as low accuracy of the conductivity method, poor repeatability of the electrochemical method, and systematic errors in the ultraviolet (UV) spectrophotometry. Among them, UV spectrophotometry is more suitable for real-time monitoring of dialysis adequacy on hemodialysis machines because of its advantages of noncontact and high sampling rate. Here, this article proposes a dialysis adequacy sensor (DAS) based on UV spectrophotometry, and develops a correction algorithm by modeling the theoretical optical path to improve real-time monitoring accuracy. The error in the urea concentration ratio is reduced by about ten times in the laboratory environment, which proves the effectiveness of the calibration algorithm. Clinical trials have demonstrated that the proposed sensor and implemented correction algorithm can precisely monitor dialysis adequacy during patient treatment, which can greatly reduce the error from 133.9% to 5.56%. The sensor reliably tracks the fluctuations in urea clearance rates, providing an effective indication of dialysis adequacy, which demonstrates strong potential for broad application among hemodialysis machines.
WOS关键词ULTRAVIOLET-ABSORBENCY ; IONIC DIALYSANCE ; UREA REMOVAL ; ONLINE ; CLEARANCE ; KT/V ; ACCURACY ; SOLUTES
资助项目National Natural Science Foundation of China[12172359] ; Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS)[ZDBS-LY-JSC014] ; CAS Interdisciplinary Innovation Team[JCTD-2020-03] ; Zhongke Technology Achievement Transfer and Transformation Center of Henan Province[2025113] ; State Key Laboratory of Structural Analysis, Optimization and Computer-Aided Engineering (CAE) Software for Industrial Equipment[GZ24109]
WOS研究方向Engineering ; Instruments & Instrumentation
语种英语
WOS记录号WOS:001571432900013
资助机构National Natural Science Foundation of China ; Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS) ; CAS Interdisciplinary Innovation Team ; Zhongke Technology Achievement Transfer and Transformation Center of Henan Province ; State Key Laboratory of Structural Analysis, Optimization and Computer-Aided Engineering (CAE) Software for Industrial Equipment
源URL[http://dspace.imech.ac.cn/handle/311007/104035]  
专题力学研究所_非线性力学国家重点实验室
通讯作者Wang, Bo; Su, Yewang
作者单位1.Zhongke Technol Achievement Transfer & Transformat, Zhengzhou 450016, Henan, Peoples R China
2.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China
4.Dalian Univ Technol, State Key Lab Struct Anal Optimizat & CAE Software, Dalian 116024, Liaoning, Peoples R China
5.Tuoren Med Device Res & Dev Inst Co Ltd, Henan Key Lab Med Polymer Mat Technol & Applicat, Tuoren Hlth Technol Ind Pk, Changyuan 453000, Henan, Peoples R China
6.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Xinfang,Wang, Bo,Zhou, Lianqiao,et al. Dialysis Adequacy Sensor With Systematic Error Correction Algorithm for Hemodialysis Machines[J]. IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT,2025,74:9.
APA Cao, Xinfang.,Wang, Bo.,Zhou, Lianqiao.,Zhang, Chunke.,Lan, Yuqun.,...&Su, Yewang.(2025).Dialysis Adequacy Sensor With Systematic Error Correction Algorithm for Hemodialysis Machines.IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT,74,9.
MLA Cao, Xinfang,et al."Dialysis Adequacy Sensor With Systematic Error Correction Algorithm for Hemodialysis Machines".IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT 74(2025):9.

入库方式： OAI收割

来源：力学研究所

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