Unraveling the formation and stabilization of vesicle penetration pore by molecular dynamics simulations
文献类型：期刊论文
| 作者 | Zheng Z(郑植)3,4,5; Zhang MK(张明焜)1,2,3,4,5; Yang Q(杨晴)3,4,5; Long M(龙勉)3,4,5; Lv SQ(吕守芹)3,4,5 |
| 刊名 | ACTA MECHANICA SINICA
 |
| 出版日期 | 2025-07-09 |
| 卷号 | 41期号:7页码:12 |
| 关键词 | Penetration pore Membrane fusion Membrane tension Molecular dynamics simulation |
| ISSN号 | 0567-7718 |
| DOI | 10.1007/s10409-025-25419-x |
| 通讯作者 | Long, Mian(mlong@imech.ac.cn) ; Lu, Shouqin(lsq@imech.ac.cn) |
| 英文摘要 | The formation of donut-shaped penetration pore upon membrane fusion in a closed lipid membrane system is of biological significance, since such the structures extensively exist in living body with various functions. However, the related formation dynamics is unclear because of the limitation of experimental techniques. This work developed a new model of intra-vesicular fusion to elaborate the formation and stabilization of penetration pores by employing molecular dynamics simulations, based on simplified spherical lipid vesicle system, and investigated the regulation of membrane lipid composition. Results showed that penetration pore could be successfully formed based on the strategy of membrane fusion. The ease of intra-vesicular fusion and penetration pore formation was closely correlated with the lipid curvature properties, where negative spontaneous curvature of lipids seemed to be unfavorable for intra-vesicle fusion. Furthermore, the inner membrane tension around the pore was much larger than other regions, which governed the penetration pore size and stability. This work provided basic understanding for vesicle penetration pore formation and stabilization mechanisms. |
| 分类号 | 一类 |
| WOS关键词 | MEMBRANE TENSION ; SOFTWARE NEWS ; FUSION ; MECHANISM ; FENESTRAE ; ACTIN ; CYTOSKELETON ; TOOLKIT ; CELLS ; GUI |
| 资助项目 | National Natural Science Foundation of China[T2394512] ; National Natural Science Foundation of China[32130061] ; National Natural Science Foundation of China[12172366] ; Scientific Instrument Developing Project of the Chinese Academy of Sciences[GJJSTD20220002] |
| WOS研究方向 | Engineering ; Mechanics |
| 语种 | 英语 |
| WOS记录号 | WOS:001527777800001 |
| 资助机构 | National Natural Science Foundation of China ; Scientific Instrument Developing Project of the Chinese Academy of Sciences |
| 其他责任者 | 龙勉，吕守芹 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/102029]  |
| 专题 | 力学研究所_国家微重力实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Chongqing Sch, Chongqing 400714, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Engn Res Ctr High Resolut & Three Dimens, Chongqing 400714, Peoples R China; 3.Univ Chinese Acad Sci s, Sch Engn Sci, Beijing 100049, Peoples R China; 4.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construction & Mechanobiol, Beijing 100190, Peoples R China; 5.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Key Lab Micrograv, Beijing 100190, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zheng Z,Zhang MK,Yang Q,et al. Unraveling the formation and stabilization of vesicle penetration pore by molecular dynamics simulations[J]. ACTA MECHANICA SINICA,2025,41(7):12. |
| APA | 郑植,张明焜,杨晴,龙勉,&吕守芹.(2025).Unraveling the formation and stabilization of vesicle penetration pore by molecular dynamics simulations.ACTA MECHANICA SINICA,41(7),12. |
| MLA | 郑植,et al."Unraveling the formation and stabilization of vesicle penetration pore by molecular dynamics simulations".ACTA MECHANICA SINICA 41.7(2025):12. |
入库方式： OAI收割
来源：力学研究所
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