AN INVESTIGATION OF THE METABOLISM OF LIQUIRITIN AND THE IMMUNOLOGICAL EFFECTS OF ITS METABOLITES
文献类型：期刊论文
| 作者 | Meng XY ; Yang SB ; Pi ZF ; Song FR ; Jiang HY ; Liu ZQ |
| 刊名 | journal of liquid chromatography & related technologies
 |
| 出版日期 | 2012 |
| 卷号 | 35期号:11页码:1538-1549 |
| 关键词 | TRADITIONAL CHINESE MEDICINE IN-VITRO GLYCYRRHIZIN HEPATITIS URINE LIVER TANG ACID |
| ISSN号 | 1082-6076 |
| 通讯作者 | jiang hy |
| 中文摘要 | the aim of the present research is to find the influence of honey in the metabolism of liquiritin by human intestinal flora to validate the folkloric use of honey-treated licorice (glycyrrhiza uralensis). the metabolites of liquiritin were analyzed by hplc-ms/ms and ft-icr-ms/ms. the immunological effects were investigated by using an in vitro splenocyte proliferation assay. in the presence of honey, liquiritin was metabolized slowly into the main metabolite (liquiritigenin), and the other metabolite (davidigenin) was only found in low abundance. but, in the absence of honey, liquiritin was rapidly transformed into liquiritigenin, and liquiritigenin was further metabolized into davidigenin, making davidigenin the main metabolite. the splenocyte proliferation assay revealed that liquiritigenin shows remarkable immuno-enhancing effects, whereas liquiritin and davidigenin exhibit little or adverse effect on the proliferation of cona-induced murine splenocytes. the presence of honey can alter the metabolism of liquiritin and, thus, influence the pharmacological effects of the licorice, rendering the honey-treated licorice as a medicine to invigorate the spleen. |
| 收录类别 | SCI收录期刊论文 |
| 语种 | 英语 |
| WOS记录号 | WOS:000305566900006 |
| 公开日期 | 2013-11-02 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/49022]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Meng XY,Yang SB,Pi ZF,et al. AN INVESTIGATION OF THE METABOLISM OF LIQUIRITIN AND THE IMMUNOLOGICAL EFFECTS OF ITS METABOLITES[J]. journal of liquid chromatography & related technologies,2012,35(11):1538-1549. |
| APA | Meng XY,Yang SB,Pi ZF,Song FR,Jiang HY,&Liu ZQ.(2012).AN INVESTIGATION OF THE METABOLISM OF LIQUIRITIN AND THE IMMUNOLOGICAL EFFECTS OF ITS METABOLITES.journal of liquid chromatography & related technologies,35(11),1538-1549. |
| MLA | Meng XY,et al."AN INVESTIGATION OF THE METABOLISM OF LIQUIRITIN AND THE IMMUNOLOGICAL EFFECTS OF ITS METABOLITES".journal of liquid chromatography & related technologies 35.11(2012):1538-1549. |
入库方式： OAI收割
来源：长春应用化学研究所
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