Sustainable production of active pharmaceutical ingredients from lignin-based benzoic acid derivatives via "demand orientation"
文献类型：期刊论文
| 作者 | Dong, Yuguo1; Dong, Lin1; Gu, Xiaoli1; Wang, Yanqin2,3; Liao, Yuhe4; Luque, Rafael5,6; Chen, Zupeng1 |
| 刊名 | GREEN CHEMISTRY
 |
| 出版日期 | 2023-05-22 |
| 卷号 | 25期号:10页码:3791-3815 |
| ISSN号 | 1463-9262 |
| DOI | 10.1039/d3gc00241a |
| 通讯作者 | Dong, Lin(donglin@njfu.edu.cn) ; Gu, Xiaoli(guxiaoli@njfu.edu.cn) ; Chen, Zupeng(czp@njfu.edu.cn) |
| 英文摘要 | Research related to lignin valorization into fine chemicals is an extremely demanding task due to the wide distribution and low economic value of depolymerization products. Benzoic acid derivatives (BADs) are the final products of the selective oxidation of the lignin side chain (i.e., p-hydroxybenzoic acid, vanillic acid, syringic acid, and benzoic acid), with favorable processibility functionality, showing great potential in the synthesis of active pharmaceutical ingredients (APIs) containing ester and carbonyl groups. Herein, this tutorial review presents our views on lignin utilization, especially using lignin-based benzoic acid derivatives (LBADs) as raw materials for the synthesis of APIs, with the aim of providing a greener, more eco-friendly approach for providing a sustainable route for the production of APIs. We first introduce the conversion of lignin or lignin platform compounds via the oxidative cleavage of C-C and C-O bonds to LBADs. Subsequently, focusing on the functional group modification strategy for the conversion of LBADs, we raise a "Demand Orientation" concept and several typical API synthesis routes. This tutorial review provides green production routes from LBADs in six instances (i.e., trimebutine, aniracetam, diethylstilbestrol, dopamine, acetaminophen, oxybuprocaine). Finally, several others APIs from LBADs via theoretically feasible and sustainable routes are proposed. Some personal perspectives are provided to highlight the opportunities within this attractive field. |
| WOS关键词 | C-C BOND ; CATALYZED OXIDATIVE CLEAVAGE ; VERATRYL ALCOHOL ; MODEL COMPOUNDS ; SELECTIVE OXIDATION ; VISIBLE-LIGHT ; AROYL CYANIDES ; CO3O4 CATALYST ; WATER REDUCER ; IONIC LIQUID |
| 资助项目 | National Natural Science Foundation of China[22202105] ; National Natural Science Foundation of China[22002043] ; Natural Science Foundation of Jiangsu Province[BK20210608] ; Natural Science Foundation of Jiangsu Higher Education Institutions of China[21KJA150003] ; RUDN University Strategic Academic Leadership Program |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000979152700001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Natural Science Foundation of Jiangsu Higher Education Institutions of China ; RUDN University Strategic Academic Leadership Program |
| 源URL | [http://ir.giec.ac.cn/handle/344007/38810]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Dong, Lin; Gu, Xiaoli; Chen, Zupeng |
| 作者单位 | 1.Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat, Nanjing 210037, Peoples R China 2.East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China 3.East China Univ Sci & Technol, Res Inst Ind Catalysis, Feringa Nobel Prize Sci Joint Res Ctr, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Energy Convers, CAS Key Lab Renewable Energy, Guangzhou 510640, Peoples R China 5.Peoples Friendship Univ Russia, RUDN Univ, 6 Miklukho Maklaya str, Moscow 117198, Russia 6.Univ ECOTEC, Km 13 5 Samborondon, EC-092302 Samborondon, Ecuador |
| 推荐引用方式 GB/T 7714 | Dong, Yuguo,Dong, Lin,Gu, Xiaoli,et al. Sustainable production of active pharmaceutical ingredients from lignin-based benzoic acid derivatives via "demand orientation"[J]. GREEN CHEMISTRY,2023,25(10):3791-3815. |
| APA | Dong, Yuguo.,Dong, Lin.,Gu, Xiaoli.,Wang, Yanqin.,Liao, Yuhe.,...&Chen, Zupeng.(2023).Sustainable production of active pharmaceutical ingredients from lignin-based benzoic acid derivatives via "demand orientation".GREEN CHEMISTRY,25(10),3791-3815. |
| MLA | Dong, Yuguo,et al."Sustainable production of active pharmaceutical ingredients from lignin-based benzoic acid derivatives via "demand orientation"".GREEN CHEMISTRY 25.10(2023):3791-3815. |
入库方式： OAI收割
来源：广州能源研究所
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