Tetrahymena Functional Genomics Database (TetraFGD): an integrated resource for Tetrahymena functional genomics
文献类型：期刊论文
| 作者 | Xiong, Jie1; Lu, Yuming1; Feng, Jinmei1,2; Yuan, Dongxia1; Tian, Miao1,3; Chang, Yue1,3; Fu, Chengjie1; Wang, Guangying1,3; Zeng, Honghui1; Miao, Wei1 |
| 刊名 | DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
 |
| 出版日期 | 2013-03-12 |
| 期号 | -页码:bat008 |
| 关键词 | GENE-EXPRESSION RNA SEQUENCE PROTEIN |
| ISSN号 | 1758-0463 |
| 通讯作者 | Zeng, HH (reprint author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China. |
| 中文摘要 | The ciliated protozoan Tetrahymena thermophila is a useful unicellular model organism for studies of eukaryotic cellular and molecular biology. Researches on T. thermophila have contributed to a series of remarkable basic biological principles. After the macronuclear genome was sequenced, substantial progress has been made in functional genomics research on T. thermophila, including genome-wide microarray analysis of the T. thermophila life cycle, a T. thermophila gene network analysis based on the microarray data and transcriptome analysis by deep RNA sequencing. To meet the growing demands for the Tetrahymena research community, we integrated these data to provide a public access database: Tetrahymena functional genomics database (TetraFGD). TetraFGD contains three major resources, including the RNA-Seq transcriptome, microarray and gene networks. The RNA-Seq data define gene structures and transcriptome, with special emphasis on exon-intron boundaries; the microarray data describe gene expression of 20 time points during three major stages of the T. thermophila life cycle; the gene network data identify potential gene-gene interactions of 15 049 genes. The TetraFGD provides user-friendly search functions that assist researchers in accessing gene models, transcripts, gene expression data and gene-gene relationships. In conclusion, the TetraFGD is an important functional genomic resource for researchers who focus on the Tetrahymena or other ciliates. |
| 英文摘要 | The ciliated protozoan Tetrahymena thermophila is a useful unicellular model organism for studies of eukaryotic cellular and molecular biology. Researches on T. thermophila have contributed to a series of remarkable basic biological principles. After the macronuclear genome was sequenced, substantial progress has been made in functional genomics research on T. thermophila, including genome-wide microarray analysis of the T. thermophila life cycle, a T. thermophila gene network analysis based on the microarray data and transcriptome analysis by deep RNA sequencing. To meet the growing demands for the Tetrahymena research community, we integrated these data to provide a public access database: Tetrahymena functional genomics database (TetraFGD). TetraFGD contains three major resources, including the RNA-Seq transcriptome, microarray and gene networks. The RNA-Seq data define gene structures and transcriptome, with special emphasis on exon-intron boundaries; the microarray data describe gene expression of 20 time points during three major stages of the T. thermophila life cycle; the gene network data identify potential gene-gene interactions of 15 049 genes. The TetraFGD provides user-friendly search functions that assist researchers in accessing gene models, transcripts, gene expression data and gene-gene relationships. In conclusion, the TetraFGD is an important functional genomic resource for researchers who focus on the Tetrahymena or other ciliates. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Mathematical & Computational Biology |
| 研究领域[WOS] | Mathematical & Computational Biology |
| 关键词[WOS] | GENE-EXPRESSION ; RNA ; SEQUENCE ; PROTEIN |
| 收录类别 | SCI |
| 资助信息 | Knowledge Innovation Program of CAS [KSCX2-EW-G-6-4]; Scientific Research Foundation for the Returned Overseas Chinese Scholars State Education Ministry; open foundation of the State Key Laboratory of Genetics Resources and Evolution [GREKF10-09]; National Scientific Data Sharing Platform for population and health, biologic medicine information center of China [2005DKA32402] |
| 语种 | 英语 |
| WOS记录号 | WOS:000316173800001 |
| 公开日期 | 2013-10-31 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/19339]  |
| 专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, Jie,Lu, Yuming,Feng, Jinmei,et al. Tetrahymena Functional Genomics Database (TetraFGD): an integrated resource for Tetrahymena functional genomics[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2013(-):bat008. |
| APA | Xiong, Jie.,Lu, Yuming.,Feng, Jinmei.,Yuan, Dongxia.,Tian, Miao.,...&Miao, Wei.(2013).Tetrahymena Functional Genomics Database (TetraFGD): an integrated resource for Tetrahymena functional genomics.DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION(-),bat008. |
| MLA | Xiong, Jie,et al."Tetrahymena Functional Genomics Database (TetraFGD): an integrated resource for Tetrahymena functional genomics".DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION .-(2013):bat008. |
入库方式： OAI收割
来源：水生生物研究所
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