Homogalacturonan enriched pectin based hydrogel enhances 6-gingerol's colitis alleviation effect via NF-xB/NLRP3 axis
文献类型：期刊论文
| 作者 | Wang, Qun1; Wang, Zhaomei2; Song, Jun3; Xu, Kangjie1; Tian, Wenni1; Cai, Xu4; Mo, Jiamei5; Cao, Yong1; Xiao, Jie1 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2023-08-01 |
| 卷号 | 245页码:12 |
| 关键词 | 6-gingerol Homogalacturonan enriched pectin Hydrogel Synergistic anti -colitis NF-xB NLRP3 axis |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2023.125282 |
| 通讯作者 | Xiao, Jie(xiaojieacademic@163.com) |
| 英文摘要 | A nanolipidcarrier (NLC) loaded homogalacturonan enriched pectin (citrus modified pectin, MCP4) hydrogel was designed as a novel colon inflammation site-specific oral delivery system for 6-gingerol (6G) (6G-NLC/MCP4 hydrogel) administration, and its colitis alleviation effect were investigated. 6G-NLC/MCP4 exhibited typical "cage-like" ultrastructure with 6G-NLC embedded in the hydrogel matrix as observed by cryoscanning electron microscope. And due to the homogalacturonan (HG) domain in MCP4 specifically combined with Galectin-3, which is overexpressed in the inflammatory region, the 6G-NLC/MCP4 hydrogel targeted to severe inflammatory region. Meanwhile, the prolonged-release characteristics of 6G-NLC provided sustained release of 6G in severe inflammatory regions. The matrix of hydrogel MCP4 and 6G achieved synergistic alleviation effects for colitis through NF-xB/NLRP3 axis. Specifically, 6G mainly regulated the NF-xB inflammatory pathway and inhibited the activity of NLRP3 protein, while MCP4 regulated the expression of Galectin-3 and peripheral clock gene Rev-Erb & alpha;/& beta; to prevent the activation of inflammasome NLRP3. |
| WOS关键词 | INFLAMMASOME ACTIVATION ; ULCERATIVE-COLITIS |
| 资助项目 | Program for Guangdong Introducing Innovative and Entrepreneurial Teams[2019ZT08N291] ; National Natural Science Foundation of China[31701556] ; Pearl Rriver's Young Scholar Project in Guangdong Province |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001024638500001 |
| 出版者 | ELSEVIER |
| 资助机构 | Program for Guangdong Introducing Innovative and Entrepreneurial Teams ; National Natural Science Foundation of China ; Pearl Rriver's Young Scholar Project in Guangdong Province |
| 源URL | [http://ir.giec.ac.cn/handle/344007/39413]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Xiao, Jie |
| 作者单位 | 1.South China Agr Univ, Coll Food Sci, Guangdong Prov Key Lab Funct Food Act Subst, Guangzhou 510642, Guangdong, Peoples R China 2.South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China 3.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Div Gastroenterol, Wuhan 430022, Peoples R China 4.Wuhan Univ, Zhongnan Hosp, Med Sci Res Ctr, Wuhan 430071, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangzhou 510640, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qun,Wang, Zhaomei,Song, Jun,et al. Homogalacturonan enriched pectin based hydrogel enhances 6-gingerol's colitis alleviation effect via NF-xB/NLRP3 axis[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,245:12. |
| APA | Wang, Qun.,Wang, Zhaomei.,Song, Jun.,Xu, Kangjie.,Tian, Wenni.,...&Xiao, Jie.(2023).Homogalacturonan enriched pectin based hydrogel enhances 6-gingerol's colitis alleviation effect via NF-xB/NLRP3 axis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,245,12. |
| MLA | Wang, Qun,et al."Homogalacturonan enriched pectin based hydrogel enhances 6-gingerol's colitis alleviation effect via NF-xB/NLRP3 axis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 245(2023):12. |
入库方式： OAI收割
来源：广州能源研究所
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