Artesunate carriers induced ferroptosis to overcome biological barriers for anti-cancer
文献类型：期刊论文
| 作者 | Huang, Qun-Fa1,2; Li, Yan-Hong1,2; Huang, Zeng-Jin1,2; Jun, Mei2; Wang, Wei2; Chen, Xiao-Li3; Wang, Guan-Hai1,2 |
| 刊名 | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
 |
| 出版日期 | 2023-09-01 |
| 卷号 | 190页码:284-293 |
| 关键词 | Artesunate Ferroptosis Redox homeostasis Charge reversal Deep penetration |
| ISSN号 | 0939-6411 |
| DOI | 10.1016/j.ejpb.2023.07.014 |
| 通讯作者 | Wang, Guan-Hai(wangguanhai@gdmu.edu.cn) |
| 英文摘要 | Artesunate (ART) has potent anticancer activity but it suffers from poor stability and low bioavailability in vivo due to the special endoperoxide moiety in the molecules. In this work, we fabricated programmable enzyme/ reactive oxygen species (ROS) responsive ART complex carriers with size and charge adaptive regulation in order to improve stability and overcome biochemical hurdles of solid tumor. The complex carries (ART/AA-PAMAM@HA) were created by electrostatic interaction between dendrimer-ART/arachidonic acid (AA) (ART/ AA-PAMAM) and hyaluronic acid (HA), which can proactively penetrate deeply into tumors and selective drug release. Specifically, ART induced Fenton reaction and produced a mass of ROS and lipid peroxides (LPO), leading to the depressing of GSH level and glutathione peroxidase 4 (GPX4) activity. Meanwhile, exogenous AA further promoted the accumulation of LPO by cascade regulating ferroptosis pathway. In the anti-tumor efficacy in vivo, the tumor inhibition ratio was achieved to 46.92%. This work shows a new anti-tumor strategy triggering ferroptosis via regulating redox homeostasis. |
| WOS关键词 | CANCER-CELLS ; IRON ; FERRITINOPHAGY ; PENETRATION ; SENSITIVITY |
| 资助项目 | GuangDong Basic and Applied Basic Research Foundation[2022A1515140026] ; GuangDong Basic and Applied Basic Research Foundation[2021A1515010097] ; Dongguan Science and Technology of Social Development Program[20211800905062] ; Discipline Construction Project of Guangdong Medical University[4SG23002G] ; Competitive allocation project of special funds for science and technology development in Zhanjiang[2021A05047] ; Innovation Program of Zhanjiang[2020LHJH005] ; Doctoral Research Start Project of Guangdong Medical University[4SG18001Gb] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001070981100001 |
| 出版者 | ELSEVIER |
| 资助机构 | GuangDong Basic and Applied Basic Research Foundation ; Dongguan Science and Technology of Social Development Program ; Discipline Construction Project of Guangdong Medical University ; Competitive allocation project of special funds for science and technology development in Zhanjiang ; Innovation Program of Zhanjiang ; Doctoral Research Start Project of Guangdong Medical University |
| 源URL | [http://ir.giec.ac.cn/handle/344007/39790]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Wang, Guan-Hai |
| 作者单位 | 1.Guangdong Med Univ, Dongguan Affiliated Hosp 1, Dongguan 523710, Peoples R China 2.Guangdong Med Univ, Sch Pharm, Dongguan 523808, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangzhou 510640, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, Qun-Fa,Li, Yan-Hong,Huang, Zeng-Jin,et al. Artesunate carriers induced ferroptosis to overcome biological barriers for anti-cancer[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2023,190:284-293. |
| APA | Huang, Qun-Fa.,Li, Yan-Hong.,Huang, Zeng-Jin.,Jun, Mei.,Wang, Wei.,...&Wang, Guan-Hai.(2023).Artesunate carriers induced ferroptosis to overcome biological barriers for anti-cancer.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,190,284-293. |
| MLA | Huang, Qun-Fa,et al."Artesunate carriers induced ferroptosis to overcome biological barriers for anti-cancer".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 190(2023):284-293. |
入库方式： OAI收割
来源：广州能源研究所
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