The suppression of hematopoiesis function in Balb/c mice induced by prolonged exposure of microcystin-LR
文献类型：期刊论文
| 作者 | Zhou, Wenshan1,2; Zhang, Xuezhen1; Xie, Ping1,2; Liang, Hualei1; Zhang, Xin1,2 |
| 刊名 | TOXICOLOGY LETTERS
 |
| 出版日期 | 2013-05-23 |
| 卷号 | 219期号:2页码:194-201 |
| 关键词 | Microcystin-LR Bone marrow cells Micronucleus Apoptosis Hematopoiesis Hematoxicology |
| ISSN号 | 0378-4274 |
| 通讯作者 | Zhang, XZ (reprint author), Huazhong Agr Univ, Coll Fisheries, Lion Hill St 1, Wuhan 430070, Peoples R China. |
| 中文摘要 | Microcystins (MCs) cause normocytic anemia in patients in a hemodialysis unit in Caruaru, Brazil in 1996, but the underlying mechanisms are still unclear. In the present study, Balb/c mice were intraperitoneally injected with microcystin-LR (MC-LR) at the doses of 0.5, 2 and 8 mu/kg body weight (bw) every 48 h for 30d. After the prolonged exposure of MC-LR, significant decreases of red blood cell count (RBC), hemoglobin (Hb) and hematocrit (Ht) were observed in 2 and 8 mu g/kg bw groups, but erythrocyte mean corpuscular volume (MCV) showed no significant changes. Significantly elevated micronucleus frequency was observed in bone marrow cells (BMCs) in all MC-LR treatments. The proliferation of BMCs significantly declined in both 2 and 8 mu g/kg bw groups. Serum levels of some hematopoietic growth factors significantly changed in 8 mu g/kg bw group, mainly including granulocyte-macrophage (GM-CSF), erythropoietin (EPO), interleukin-3 (IL-3) and TNF-alpha. The transcriptional levels of these 4 genes in BMCs were also significantly changed in 8 mu g/kg bw group. MC-LR exposure significantly increased the apoptosis rates in all MC-LR treatments. The present study indicates prolonged exposure of MC-LR induces normocytic anemia, and the disturbed hematopoietic growth factors and BMCs apoptosis are responsible for this normocytic anemia. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| 英文摘要 | Microcystins (MCs) cause normocytic anemia in patients in a hemodialysis unit in Caruaru, Brazil in 1996, but the underlying mechanisms are still unclear. In the present study, Balb/c mice were intraperitoneally injected with microcystin-LR (MC-LR) at the doses of 0.5, 2 and 8 mu/kg body weight (bw) every 48 h for 30d. After the prolonged exposure of MC-LR, significant decreases of red blood cell count (RBC), hemoglobin (Hb) and hematocrit (Ht) were observed in 2 and 8 mu g/kg bw groups, but erythrocyte mean corpuscular volume (MCV) showed no significant changes. Significantly elevated micronucleus frequency was observed in bone marrow cells (BMCs) in all MC-LR treatments. The proliferation of BMCs significantly declined in both 2 and 8 mu g/kg bw groups. Serum levels of some hematopoietic growth factors significantly changed in 8 mu g/kg bw group, mainly including granulocyte-macrophage (GM-CSF), erythropoietin (EPO), interleukin-3 (IL-3) and TNF-alpha. The transcriptional levels of these 4 genes in BMCs were also significantly changed in 8 mu g/kg bw group. MC-LR exposure significantly increased the apoptosis rates in all MC-LR treatments. The present study indicates prolonged exposure of MC-LR induces normocytic anemia, and the disturbed hematopoietic growth factors and BMCs apoptosis are responsible for this normocytic anemia. (C) 2013 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Toxicology |
| 研究领域[WOS] | Toxicology |
| 关键词[WOS] | NECROSIS-FACTOR-ALPHA ; BONE-MARROW ; CYANOBACTERIA BLOOM ; MICRONUCLEUS ASSAY ; PERIPHERAL-BLOOD ; PROGENITOR CELLS ; CYTOCHROME-C ; DNA-DAMAGE ; ANEMIA ; PROLIFERATION |
| 收录类别 | SCI |
| 资助信息 | National Natural Science Foundation of China [30800160] |
| 语种 | 英语 |
| WOS记录号 | WOS:000318838300012 |
| 公开日期 | 2013-10-31 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/19286]  |
| 专题 | 水生生物研究所_淡水生态学研究中心_期刊论文 |
| 作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wenshan,Zhang, Xuezhen,Xie, Ping,et al. The suppression of hematopoiesis function in Balb/c mice induced by prolonged exposure of microcystin-LR[J]. TOXICOLOGY LETTERS,2013,219(2):194-201. |
| APA | Zhou, Wenshan,Zhang, Xuezhen,Xie, Ping,Liang, Hualei,&Zhang, Xin.(2013).The suppression of hematopoiesis function in Balb/c mice induced by prolonged exposure of microcystin-LR.TOXICOLOGY LETTERS,219(2),194-201. |
| MLA | Zhou, Wenshan,et al."The suppression of hematopoiesis function in Balb/c mice induced by prolonged exposure of microcystin-LR".TOXICOLOGY LETTERS 219.2(2013):194-201. |
入库方式： OAI收割
来源：水生生物研究所
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