Sericin "hairpin structure"-based multifunctional anthocyanin nanoencapsulation for remodeling ROS-dependent cutaneous wound healing
文献类型：期刊论文
| 作者 | Zhang, Lei2,3; Hao, Minglu4,5; Yao, Liang6; Xing, Cheng2,3; Wen, Qingmei1; Zhang, Zhining2,3; Yu, Jingmou2,3; Wang, Jun6; Xing, Dongming5,7; Zheng, Tao1 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2023-11-01 |
| 卷号 | 475页码:14 |
| 关键词 | Silk sericin Anthocyanin Encapsulation mechanism Stability enhancement Skin wound healing |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2023.145863 |
| 通讯作者 | Zhang, Lei(l78zhang@uwaterloo.ca) ; Chen, P.(p4chen@uwaterloo.ca) |
| 英文摘要 | Anthocyanins, a class of polyphenols possessing potent antioxidant properties, are limited in their applicability in biomedical industries owing to their low stability. This study harnessed the bioactive silk sericin to encapsulate anthocyanins and thereby conferred enhanced stability and multifunctional bioactivity. Meanwhile, experi-mental and computational methods were used to systematically probe the interaction between silk sericin and anthocyanins. The hydrogel formulation of silk sericin displayed higher encapsulation efficiency and concomi-tant improvements in stability under diverse conditions such as pH, metals, and temperature. Molecular simu-lations revealed that the amino acids, phenylalanine and tyrosine, with a hairpin structure were pivotal in the interaction between the two components, culminating in the formation of nanocomposites, a finding corrobo-rated by the experimental results using various spectroscopic techniques. Significantly, the encapsulated an-thocyanins exhibited enhanced bioactivity, particularly in their reactive oxygen species (ROS) scavenging ability. Leveraging the potent antioxidant properties of silk sericin and anthocyanins, the formulation evinced ROS-triggered wound healing functions by modulating factors such as TGF-beta, IL-1 beta, TNF-alpha, IL-10, and VEGF. This study highlights the potential of utilizing two bioactive components derived from the same sericultural system to enhance stability and regulate bioactivity in tissue engineering applications. |
| WOS关键词 | TYPE-2 IMMUNITY ; SILK SERICIN ; PROTEIN ; HYDROGEL ; DELIVERY ; NANOPARTICLES ; ENCAPSULATION ; REGENERATION ; ANTIOXIDANT ; METABOLISM |
| 资助项目 | Canada Mitacs Fellowship[IT18262] ; Natural Science Foundation of Jiangsu Province, China[BK20190960] ; Natural Science Foundation of the Jiangsu Higher Edu-cation Institutions of China[19KJB180014] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001079429700001 |
| 出版者 | ELSEVIER SCIENCE SA |
| 资助机构 | Canada Mitacs Fellowship ; Natural Science Foundation of Jiangsu Province, China ; Natural Science Foundation of the Jiangsu Higher Edu-cation Institutions of China |
| 源URL | [http://ir.giec.ac.cn/handle/344007/39964]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Zhang, Lei; Chen, P. |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangzhou 510640, Peoples R China 2.Univ Waterloo, Dept Chem Engn, Waterloo, ON N2L 3G1, Canada 3.Univ Waterloo, Waterloo Inst Nanotechnol, Waterloo, ON N2L 3G1, Canada 4.Qilu Univ Technol, Adv Mat Inst, Shandong Acad Sci, Jinan 250014, Peoples R China 5.Qingdao Univ, Affiliated Hosp, Canc Inst, Qingdao 266071, Peoples R China 6.Jiangsu Univ Sci & Technol, Sericultural Res Inst, Coll Biotechnol, Zhenjiang 212003, Jiangsu, Peoples R China 7.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Lei,Hao, Minglu,Yao, Liang,et al. Sericin "hairpin structure"-based multifunctional anthocyanin nanoencapsulation for remodeling ROS-dependent cutaneous wound healing[J]. CHEMICAL ENGINEERING JOURNAL,2023,475:14. |
| APA | Zhang, Lei.,Hao, Minglu.,Yao, Liang.,Xing, Cheng.,Wen, Qingmei.,...&Chen, P..(2023).Sericin "hairpin structure"-based multifunctional anthocyanin nanoencapsulation for remodeling ROS-dependent cutaneous wound healing.CHEMICAL ENGINEERING JOURNAL,475,14. |
| MLA | Zhang, Lei,et al."Sericin "hairpin structure"-based multifunctional anthocyanin nanoencapsulation for remodeling ROS-dependent cutaneous wound healing".CHEMICAL ENGINEERING JOURNAL 475(2023):14. |
入库方式： OAI收割
来源：广州能源研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。