Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)
文献类型：期刊论文
| 作者 | Sun, Yanhong1,2; Yu, Xiaomu1; Tong, Jingou1 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2012-11-01 |
| 卷号 | 13期号:11页码:14956-14961 |
| 关键词 | Myostatin (MSTN) single nucleotide polymorphisms (SNPs) common carp (Cyprinus carpio L.) growth traits association analysis |
| ISSN号 | 1422-0067 |
| 通讯作者 | Tong, JG (reprint author), Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China. |
| 中文摘要 | Myostatin (MSTN) is a member of the transforming growth factor-beta superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp. |
| 英文摘要 | Myostatin (MSTN) is a member of the transforming growth factor-beta superfamily that negatively regulates skeletal muscle development and growth. In the present study, partial genomic fragments of MSTN were screened for single nucleotide polymorphisms (SNPs) in selected common carp individuals from wild populations, and two SNPs in intron 2 (c.371 + 749A > G, c.371 + 781T > C) and two synonymous SNPs in exon 3 (c.42A > G, c.72C > T) were identified. Genotyping by direct sequencing of polymerase chain reaction (PCR) products for these four SNPs were performed in 162 individuals from a commercial hatchery population. Association analysis showed that two SNPs in exon 3 were significantly associated with body weight (BW) and condition factor (K), and haplotype analyses revealed that haplotype H7H8 showed better growth performance. Our results demonstrated that some of the SNPs in MSTN may have positive effects on growth traits and suggested that MSTN could be a candidate gene for growth and marker-assisted selection in common carp. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | SHEEP OVIS-ARIES ; MSTN ; IDENTIFICATION ; POPULATION ; FATNESS ; WEIGHT ; REGION |
| 收录类别 | SCI |
| 资助信息 | Ministry of Science and Technology [2010CB126305]; Minstry of Agriculture [2011-G12]; State Key Laboratory of Freshwater Ecology and Biotechnology of China [2011 FBZ20] |
| 语种 | 英语 |
| WOS记录号 | WOS:000311425000073 |
| 公开日期 | 2013-10-31 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/19316]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yanhong,Yu, Xiaomu,Tong, Jingou. Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2012,13(11):14956-14961. |
| APA | Sun, Yanhong,Yu, Xiaomu,&Tong, Jingou.(2012).Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,13(11),14956-14961. |
| MLA | Sun, Yanhong,et al."Polymorphisms in Myostatin Gene and Associations with Growth Traits in the Common Carp (Cyprinus carpio L.)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13.11(2012):14956-14961. |
入库方式： OAI收割
来源：水生生物研究所
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