Exposure to OPFRs Is Associated with Obesity and Dysregulated Serum Lipid Profiles: Data from 2017-2018 NHANES
文献类型：期刊论文
| 作者 | Li, He1; Li, Fenglin1,2; Zhou, Chaoyi2,3; Bu, Jifan1,2; Yang, Hao1,2; Zhong, Liangchen1,2; Xing, Weilong2; Li, Liangzhong4 |
| 刊名 | METABOLITES
 |
| 出版日期 | 2024-02-01 |
| 卷号 | 14期号:2页码:14 |
| 关键词 | flame retardant obesity BMI serum lipid NHANES |
| DOI | 10.3390/metabo14020124 |
| 通讯作者 | Xing, Weilong(xingweilong@nies.org) ; Li, Liangzhong(lilz@ms.giec.ac.cn) |
| 英文摘要 | Widespread exposure to organophosphorus flame retardants (OPFRs) has been observed in the general population. Emerging studies have revealed OPFRs possess endocrine-disturbing properties. The present study aims to assess the association between urinary metabolites of OPFRs, BMI, and serum lipid profiles. Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 were obtained, with 1334 adults enrolled in the current study. Urinary concentrations of bis (1-chloro-2-propyl) phosphate (BCIPP), bis(2-chloroethyl) phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), dibutyl phosphate (DBUP), and diphenyl phosphate (DPHP) were quantified to assess OPFR exposure. Covariate-adjusted linear and logistic regression models were conducted to explore the associations between log2-transformed concentrations of OPFR metabolites, BMI, obesity, and serum lipid profiles. Stratified analyses were performed to assess the heterogeneity of associations by age, gender, race, etc. Positive associations were found between OPFR exposure and the risk of obesity. The multivariate linear analysis indicated that a one-unit increase in log2-transformed urinary concentrations of BCEP and BDCPP was associated with 0.27 (95% CI: 0.02-0.52, p = 0.0338) and 0.56 (95% CI: 0.25-0.87, p = 0.0004) higher BMI value, respectively. One log2-unit increase in urinary BCEP and BDCPP concentrations was associated with 1.1-fold (95% CI: 1.02-1.18, p = 0.0096) and 1.19-fold (95% CI: 1.09-1.30, p = 0.0001) risk for developing obesity. Furthermore, the non-linear relationship between exposure to OPFRs and obesity was identified. Additionally, multivariable linear regression showed that urinary DPHP concentrations were inversely correlated with serum triglyceride (TG) levels (beta = -7.41, 95% CI: -12.13 to -2.68, p = 0.0022). However, no other OPFR metabolites were found to be significantly statistically associated with serum lipid levels after adjusting for potential confounders. In conclusion, environmental exposure to OPFRs might contribute to obesity and dysregulated TG concentrations in adults. Future prospective research is warranted to confirm the causal relationship between metabolites of OPFRs and obesity. |
| WOS关键词 | ORGANOPHOSPHATE FLAME RETARDANTS ; TRIPHENYL PHOSPHATE ; FIREMASTER(R) 550 ; CYTOTOXICITY ; ACCUMULATION ; METABOLITES ; ADULTS |
| 资助项目 | National Natural Science Foundation of China ; Centers for Disease Control and Prevention (CDC) |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001172342400001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China ; Centers for Disease Control and Prevention (CDC) |
| 源URL | [http://ir.giec.ac.cn/handle/344007/41451]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Xing, Weilong; Li, Liangzhong |
| 作者单位 | 1.Southeast Univ, Sch Civil Engn, Nanjing 210096, Peoples R China 2.Minist Ecol & Environm MEE, Nanjing Inst Environm Sci, Lab Pesticide Environm Assessment & Pollut Control, Nanjing 210042, Peoples R China 3.Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang 212003, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Energy Convers, CAS Key Lab Renewable Energy, Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou 510640, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, He,Li, Fenglin,Zhou, Chaoyi,et al. Exposure to OPFRs Is Associated with Obesity and Dysregulated Serum Lipid Profiles: Data from 2017-2018 NHANES[J]. METABOLITES,2024,14(2):14. |
| APA | Li, He.,Li, Fenglin.,Zhou, Chaoyi.,Bu, Jifan.,Yang, Hao.,...&Li, Liangzhong.(2024).Exposure to OPFRs Is Associated with Obesity and Dysregulated Serum Lipid Profiles: Data from 2017-2018 NHANES.METABOLITES,14(2),14. |
| MLA | Li, He,et al."Exposure to OPFRs Is Associated with Obesity and Dysregulated Serum Lipid Profiles: Data from 2017-2018 NHANES".METABOLITES 14.2(2024):14. |
入库方式： OAI收割
来源：广州能源研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。