Discovery of two novel bioactive algicidal substances from Brevibacillus sp. via metabolomics profiling and back-validation
文献类型：期刊论文
| 作者 | Liu, Fen2,3,4; Feng, Siran1; Al-Haimi, Akram Ali Nasser Mansoor2,3,4; Zhu, Shunni2,3,4; Chen, Huanjun2,3,4; Feng, Pingzhong2,3,4; Wang, Zhongming2,3,4; Qin, Lei2,3,4 |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2024-05-05 |
| 卷号 | 469页码:10 |
| 关键词 | Algicidal substances Metabolomics profiling Photosynthetic activity 4-Acetamidobutanoic acid 8-Hydroxyquinoline |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2024.133985 |
| 通讯作者 | Qin, Lei(qinlei@ms.giec.ac.cn) |
| 英文摘要 | Identifying potent bacterial algicidal agents is essential for the development of effective, safe, and economically viable algaecides. Challenges in isolating and purifying these substances from complex secretions have impeded progress in this field. Metabolomics profiling, an efficient strategy for identifying metabolites, was pioneered in identifying bacterial algicidal substances in this study. Extracellular secretions from different generations of the algicidal bacterium Brevibacillus sp. were isolated for comprehensive analysis. Specifically, a higher algicidal efficacy was observed in the secretion from Generation 3 (G3) of Brevibacillus sp. compared to Generation 1 (G1). Subsequent metabolomics profiling comparing G3 and 1 revealed 83 significantly up-regulated metabolites, of which 9 were identified as potential algicidal candidates. Back-validation highlighted the potency of 4-acetamidobutanoic acid (4-ABC) and 8-hydroxyquinoline (8-HQL), which exhibited robust algicidal activity with 3dEC50 values of 6.40 mg/L and 92.90 mu g/L, respectively. These substances disrupted photosynthetic activity in M. aeruginosa by ceasing electron transfer in PSII, like the impact exerted by Brevibacillus sp. secretion. These findings confirmed that 4-ABC and 8-HQL were the main algicidal components derived from Brevibacillus sp.. Thus, this study presents a streamlined strategy for identifying bacterial algicidal substances and unveils two novel and highly active algicidal substances. Environmental Implication: Harmful cyanobacterial blooms (HCBs) pose significant environmental problems and health effects to humans and other organisms. The increasing frequency of HCBs has emerged as a pressing global concern. Bacterial-derived algicidal substances are expected to serve as effective, safe, and economically viable algaecides against HCBs. This study presents a streamlined strategy for identifying bacterial algicidal substances and unveils two novel substances (4-ABC and 8-HQL). These two substances demonstrate remarkable algicidal activity and disrupt the photosynthetic system in M. aeruginosa. They hold potential as prospective algaecides for addressing HCBs. |
| WOS关键词 | TOXICITY ; EXPOSURE ; REMOVAL ; WATER ; MS |
| 资助项目 | National Key R & D Program of China[2022YFE0207100] |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001218814300001 |
| 出版者 | ELSEVIER |
| 资助机构 | National Key R & D Program of China |
| 源URL | [http://ir.giec.ac.cn/handle/344007/41595]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Qin, Lei |
| 作者单位 | 1.Univ Technol Sydney, Ctr Technol Water & Wastewater, Sch Civil & Environm Engn, Sydney, NSW 2007, Australia 2.Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou 510640, Peoples R China 3.CAS Key Lab Renewable Energy, Guangzhou 510640, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangzhou 510640, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Fen,Feng, Siran,Al-Haimi, Akram Ali Nasser Mansoor,et al. Discovery of two novel bioactive algicidal substances from Brevibacillus sp. via metabolomics profiling and back-validation[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,469:10. |
| APA | Liu, Fen.,Feng, Siran.,Al-Haimi, Akram Ali Nasser Mansoor.,Zhu, Shunni.,Chen, Huanjun.,...&Qin, Lei.(2024).Discovery of two novel bioactive algicidal substances from Brevibacillus sp. via metabolomics profiling and back-validation.JOURNAL OF HAZARDOUS MATERIALS,469,10. |
| MLA | Liu, Fen,et al."Discovery of two novel bioactive algicidal substances from Brevibacillus sp. via metabolomics profiling and back-validation".JOURNAL OF HAZARDOUS MATERIALS 469(2024):10. |
入库方式： OAI收割
来源：广州能源研究所
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