Generation of environmentally persistent free radicals on photoaged tire wear particles and their neurotoxic effects on neurotransmission in Caenorhabditis elegans
文献类型：期刊论文
| 作者 | Gu, Yulun2; Jiang, Yongqi2; Chen, Xiaoxia2; Li, Liangzhong1; Chen, Haibo2; Chen, Jinyu2; Wang, Chen2; Yu, Jun2; Chen, Chao2; Li, Hui2 |
| 刊名 | ENVIRONMENT INTERNATIONAL
 |
| 出版日期 | 2024-04-01 |
| 卷号 | 186页码:10 |
| 关键词 | C. elegans EPFRs generation TWP photoaging Neurotransmission Neurotoxicity |
| ISSN号 | 0160-4120 |
| DOI | 10.1016/j.envint.2024.108640 |
| 通讯作者 | Chen, Haibo(chenhaibo@shu.edu.cn) ; Li, Hui(huili2018@shu.edu.cn) |
| 英文摘要 | Tire wear particles (TWP) are a prevalent form of microplastics (MPs) extensively distributed in the environment, raising concerns about their environmental behaviors and risks. However, knowledge regarding the properties and toxicity of these particles at environmentally relevant concentrations, specifically regarding the role of environmentally persistent free radicals (EPFRs) generated during TWP photoaging, remains limited. In this study, the evolution of EPFRs on TWP under different photoaging times and their adverse effects on Caenorhabditis elegans were systematically investigated. The photoaging process primarily resulted in the formation of EPFRs and reactive oxygen species (O-2(center dot-) , center dot OH, and O-1(2)), altering the physicochemical properties of TWP. The exposure of nematodes to 100 mu g/L of TWP-50 (TWP with a photoaging time of 50 d) led to a significant decrease in locomotory behaviors (e.g., head thrashes, body bends, and wavelength) and neurotransmitter contents (e.g., dopamine, glutamate, and serotonin). Similarly, the expression of neurotransmission-related genes was reduced in nematodes exposed to TWP-50. Furthermore, the addition of free-radical inhibitors significantly suppressed TWP-induced neurotoxicity. Notably, correlation analysis revealed a significantly negative correlation between EPFRs levels and the locomotory behaviors and neurotransmitter contents of nematodes. Thus, it was concluded that EPFRs on photoaged TWP induce neurotoxicity by affecting neurotransmission. These findings elucidate the toxicity effects and mechanisms of EPFRs, emphasizing the importance of considering their contributions when evaluating the environmental risks associated with TWP. |
| WOS关键词 | TOXICITY ; MECHANISMS ; MODEL |
| 资助项目 | National Natural Science Foundation of China[42125706] ; National Natural Science Foundation of China[42077401] ; China Postdoctoral Science Foundation[2022 M722030] |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001233945700001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | National Natural Science Foundation of China ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.giec.ac.cn/handle/344007/41897]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Chen, Haibo; Li, Hui |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Energy Convers, CAS Key Lab Renewable Energy, Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou 510640, Peoples R China 2.Shanghai Univ, Inst Environm Pollut & Hlth, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Yulun,Jiang, Yongqi,Chen, Xiaoxia,et al. Generation of environmentally persistent free radicals on photoaged tire wear particles and their neurotoxic effects on neurotransmission in Caenorhabditis elegans[J]. ENVIRONMENT INTERNATIONAL,2024,186:10. |
| APA | Gu, Yulun.,Jiang, Yongqi.,Chen, Xiaoxia.,Li, Liangzhong.,Chen, Haibo.,...&Li, Hui.(2024).Generation of environmentally persistent free radicals on photoaged tire wear particles and their neurotoxic effects on neurotransmission in Caenorhabditis elegans.ENVIRONMENT INTERNATIONAL,186,10. |
| MLA | Gu, Yulun,et al."Generation of environmentally persistent free radicals on photoaged tire wear particles and their neurotoxic effects on neurotransmission in Caenorhabditis elegans".ENVIRONMENT INTERNATIONAL 186(2024):10. |
入库方式： OAI收割
来源：广州能源研究所
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