Synergistic antibacterial and antifouling wound dressings: Integration of photothermal-activated no release and zwitterionic surface modification
文献类型：期刊论文
| 作者 | Li, Yan-Hong3; Huang, Zeng-Jin3; Zhang, Jia-Qi3; Ye, Meng -Nan3; Jun, Mei3; Wang, Wei3; Chen, Xiao-Li2; Wang, Guan-Hai1,3 |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2024-05-25 |
| 卷号 | 657页码:11 |
| 关键词 | Nitric oxide Zwitterionic wound dressing Bacterial infections Biofilm |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2024.124160 |
| 通讯作者 | Wang, Wei(wangguanhai@gdmu.edu.cn) ; Chen, Xiao-Li(chenxl@ms.giec.ac.cn) ; Wang, Guan-Hai(wangguanhai@gdmu.edu.cn) |
| 英文摘要 | Addressing the pervasive issue of bacteria and biofilm infections is crucial in the development of advanced antifouling wound dressings. In this study, a novel wound healing treatment using sulfobetaine (SBMA) decorated electrospun fibrous membrane based on polycaprolactone (PCL)/nitric oxide (NO) donors was developed. The fabrication involved a dual strategy, first integrating NO donors into mesoporous polydopamine (MPDA) and complexed with PCL/PEI to electrospin nanofibers. The fibrous membrane exhibited a potent antibacterial response upon irradiation at 808 nm, owing to a combination of NO and photothermal effect that effectively targets bacteria and disrupts biofilms. Surface functionalization of the membrane with PEI allowed for the attachment of SBMA via Michael addition, fabricating a zwitterionic surface, which significantly hinders protein adsorption and reduces biofilm formation on the wound dressing. In vitro and in vivo assessments confirmed the rapid bactericidal capabilities and its efficacy in biofilm eradication. Combining photothermal activity, targeted NO release and antifouling surface, this multifaceted wound dressing addresses key challenges in bacterial infection management and biofilm eradication, promoting efficient wound healing. |
| WOS关键词 | MACROPHAGE ; DELIVERY |
| 资助项目 | GuangDong Basic and Applied Basic Research Foundation[2022A1515140026] ; GuangDong Basic and Applied Basic Research Foundation[2020A1515110902] ; Dongguan Science and Technology of Social Development Program[20211800905062] ; Competitive allocation project of special funds for science and technology development in Zhanjiang[2021A05047] ; Medical Scientific Research Foundation of Guangdong Province[B2023240] ; Key Laboratory of Polymeric Composite and Functional Materials of Ministry of Education[2022A01] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001235819100001 |
| 出版者 | ELSEVIER |
| 资助机构 | GuangDong Basic and Applied Basic Research Foundation ; Dongguan Science and Technology of Social Development Program ; Competitive allocation project of special funds for science and technology development in Zhanjiang ; Medical Scientific Research Foundation of Guangdong Province ; Key Laboratory of Polymeric Composite and Functional Materials of Ministry of Education |
| 源URL | [http://ir.giec.ac.cn/handle/344007/41955]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Wang, Wei; Chen, Xiao-Li; Wang, Guan-Hai |
| 作者单位 | 1.Sun Yat Sen Univ, PCFM Lab, Guangzhou 510275, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Energy Convers, Guangzhou 510640, Guangdong, Peoples R China 3.Guangdong Med Univ, Dongguan Affiliated Hosp 1, Sch Pharm, Dongguan 523710, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yan-Hong,Huang, Zeng-Jin,Zhang, Jia-Qi,et al. Synergistic antibacterial and antifouling wound dressings: Integration of photothermal-activated no release and zwitterionic surface modification[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2024,657:11. |
| APA | Li, Yan-Hong.,Huang, Zeng-Jin.,Zhang, Jia-Qi.,Ye, Meng -Nan.,Jun, Mei.,...&Wang, Guan-Hai.(2024).Synergistic antibacterial and antifouling wound dressings: Integration of photothermal-activated no release and zwitterionic surface modification.INTERNATIONAL JOURNAL OF PHARMACEUTICS,657,11. |
| MLA | Li, Yan-Hong,et al."Synergistic antibacterial and antifouling wound dressings: Integration of photothermal-activated no release and zwitterionic surface modification".INTERNATIONAL JOURNAL OF PHARMACEUTICS 657(2024):11. |
入库方式： OAI收割
来源：广州能源研究所
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