Design of short-wave infrared resonant Raman reporters with near-zero fluorescence background for SERRS imaging-guided elimination of bacteria biofilms
文献类型：期刊论文
| 作者 | Zhou, Wenhao1,2; Li, Jin2 |
| 刊名 | CHEMICAL ENGINEERING JOURNAL
 |
| 出版日期 | 2025-10-15 |
| 卷号 | 522页码:16 |
| 关键词 | Short-wave infrared Raman reporters SERRS imaging Bacteria biofilms Photothermal ablation |
| ISSN号 | 1385-8947 |
| DOI | 10.1016/j.cej.2025.167185 |
| 通讯作者 | Li, Jin(jinli@yic.ac.cn) |
| 英文摘要 | Surface-enhanced resonance Raman scattering (SERRS) in short-wave infrared (SWIR) window presents an ultrasensitive technique for deep-tissue in vivo imaging and therapy. However, research in the design of SERRS probes has so far mainly focused on plasmonic substrates and lacks in-depth exploration of resonant Raman reporters with suppressed fluorescence backgrounds. In this work, we report a simple ionic molecular engineering strategy to develop SWIR quenchers as nonfluorescent Raman reporters for ultrasensitive SERRS probes towards phototheranostics of bacterial biofilm. Compared to neutral compounds, the resultant ionic ones expand its absorption to SWIR region while minimizing fluorescence emission to zero, thus offering clear background for Raman scattering. Ultrafast spectroscopy uncovers the picosecond internal conversion process as the nonemissive mechanism of tetrabutylammonium bis(bis(4-methoxyphenyl)dithiocarbamato)nickelate (iQ2) quenchers. iQ2 based nanoprobes demonstrate strong fluorescence-free SERRS signals, exceptional photostability (tau = 10,155 s) and synergistic enhanced photothermal conversion efficiency (61.4 %) in SWIR window, allowing for prolonged non-invasive SERRS monitoring of bacterial biofilm during treatment. Furthermore, in vivo experiments firmly demonstrate that the SWIR nanoprobes perform well in both Acinetobacter baumannii biofilminduced skin infection mouse model and methicillin-resistant Staphylococcus aureus biofilm-induced keratitis model. This work not only presents a simple strategy for developing long-wavelength quencher Raman reporters, but also offers a fluorescence-free nanotheranostic platform to treat bacterial infection. |
| WOS关键词 | MOLECULE |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001561274700001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40805]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 通讯作者 | Li, Jin |
| 作者单位 | 1.Zhejiang Normal Univ, Coll Chem & Mat Sci, Key Lab Minist Educ Adv Catalysis Mat, Jinhua 321004, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wenhao,Li, Jin. Design of short-wave infrared resonant Raman reporters with near-zero fluorescence background for SERRS imaging-guided elimination of bacteria biofilms[J]. CHEMICAL ENGINEERING JOURNAL,2025,522:16. |
| APA | Zhou, Wenhao,&Li, Jin.(2025).Design of short-wave infrared resonant Raman reporters with near-zero fluorescence background for SERRS imaging-guided elimination of bacteria biofilms.CHEMICAL ENGINEERING JOURNAL,522,16. |
| MLA | Zhou, Wenhao,et al."Design of short-wave infrared resonant Raman reporters with near-zero fluorescence background for SERRS imaging-guided elimination of bacteria biofilms".CHEMICAL ENGINEERING JOURNAL 522(2025):16. |
入库方式： OAI收割
来源：烟台海岸带研究所
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