Synthesis and characterization of selenourea-functionalized chitosan derivatives with enhanced antioxidant activity
文献类型：期刊论文
| 作者 | Wang, Linqing1,3; Han, Xiangru1,3; Tian, Liguang4; Yuan, Yuting2; Zhang, Jingjing3; Mi, Yingqi3; Guo, Zhanyong2,3; Dong, Fang3 |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2025-11-01 |
| 卷号 | 557页码:12 |
| 关键词 | Selenourea Chitosan derivatives Antioxidant activity Cytotoxicity |
| ISSN号 | 0008-6215 |
| DOI | 10.1016/j.carres.2025.109642 |
| 通讯作者 | Guo, Zhanyong(zhanyongguo@hotmail.com) ; Dong, Fang(fdong@yic.ac.cn) |
| 英文摘要 | Selenium, an essential micronutrient for human health, has garnered significant interest owing to its multifaceted biological activities including antioxidant, anti-inflammatory, and antitumor properties. In this study, 14 novel chitosan derivatives bearing selenourea groups were synthesized by incorporating selenium into chitosan via nucleophilic substitution reactions. Structural confirmation was achieved through FTIR, H-1 NMR, and ICP-MS analyses, confirming successful selenium incorporation. The derivatives demonstrated superior antioxidant performance, achieving >85 % DPPH radical scavenging at 0.8 mg/mL and exceptional superoxide anion radical inhibition (>95 % at 0.4 mg/mL), surpassing conventional urea-chitosan analogues (<75 % under identical conditions) from our previous study. Biocompatibility was assessed via MTT assay, revealing no significant cytotoxicity in L929 cells at concentrations <= 125 mu g/mL. These selenourea-modified chitosan derivatives demonstrate potential as novel selenium-enriched dietary supplements and antioxidants for health foods and pharmaceuticals. |
| WOS关键词 | THIOUREA ; UREA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001558121800002 |
| 资助机构 | Shandong Key R & D Plan, Major Scientific and Technological Innovation Project ; Natural Science Foundation of Shandong Province of China ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40808]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 |
| 通讯作者 | Guo, Zhanyong; Dong, Fang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Jiangsu Ocean Univ, Coll Marine Life & Fisheries, Lianyungang 222005, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 4.Yantai Agr Technol Extens Ctr, Yantai 264001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Linqing,Han, Xiangru,Tian, Liguang,et al. Synthesis and characterization of selenourea-functionalized chitosan derivatives with enhanced antioxidant activity[J]. CARBOHYDRATE RESEARCH,2025,557:12. |
| APA | Wang, Linqing.,Han, Xiangru.,Tian, Liguang.,Yuan, Yuting.,Zhang, Jingjing.,...&Dong, Fang.(2025).Synthesis and characterization of selenourea-functionalized chitosan derivatives with enhanced antioxidant activity.CARBOHYDRATE RESEARCH,557,12. |
| MLA | Wang, Linqing,et al."Synthesis and characterization of selenourea-functionalized chitosan derivatives with enhanced antioxidant activity".CARBOHYDRATE RESEARCH 557(2025):12. |
入库方式： OAI收割
来源：烟台海岸带研究所
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